Publications by authors named "Iulia Macavei"
Article Synopsis
- Gene duplication, particularly of the porin OmpF, plays a significant role in the evolution of microbial genomes, impacting their interaction with host plants, especially in the case of soft rot disease.
- The OmpF gene duplication was found to be detrimental to the virulence of the pathogen, thus contradicting the typical idea that duplicated genes always confer an advantage.
- The regulation of the EnvZ-OmpR system, which responds to pH changes, is complicated by plant defenses that produce phenolic acids, ultimately suppressing the expression of potentially harmful genes during infection.
Article Synopsis
- The study investigates how different levels of expression of virulence proteins in a bacterial pathogen relate to the severity of staphylococcal pneumonia in patients, highlighting the challenges of measuring these levels consistently.
- Using a targeted proteomics technique, the researchers analyzed 136 isolates from French patients and identified specific virulence factors that predict severe symptoms like leukopenia and hemoptysis, as well as patient survival.
- Notably, the expression of the Panton-Valentine leucocidin was found to be a significant predictor of mortality, suggesting that targeted proteomics could be valuable for understanding infection dynamics in other bacterial diseases.