[The characteristics of population health in social ecological conditions of the Primorskiĭ Kraĭ].

The article presents the results of sociological survey of residents of different bioclimatic zones of urbanized and rural territories of different bioclimatic zones of the Primorsky Kraiy in municipalities with different demographic, ecological and social characteristics. The analysis of survey data using the technique of P.V.

[Prevention and treatment of anemia during endoprosthetic replacement of large joints].

Endoprosthetic replacement of large joints is frequently followed by great blood loss and evolving postoperative anemia. Three hundred and thirty-seven cases of endoprosthetic hip joint replacement were retrospectively analyzed. The total frequency of allogenic hemotransfusion was 16.

[Prevalence of cancer in the Primorye Territory: ecological and hygienic aspects].

By using the system analysis, the authors estimate the prevalence of cancer diseases upon exposure to many environmental factors. They describe a formula of the integrated exposure index. Application of the information-aentropion analysis identifies habitat modules that affect cancer morbidity.

[Screening procedures in detection of oncological pathology in men].

The incidence of malignant neoplasms in men is higher versus women residing in Maritime Territory; neoplasms of the urogenital system account for an essential portion (13.6%) of all discussed diseases. Reduced funding to patient-care facilities, worse provision of hospitals and clinics with practitioners and paramedical personnel and minimal logistics supplies to medical facilities are the main causes that affect the quality of oncological medical care rendered to residents of Maritime Territory.

[Experience with therapy of prostate cancer in the Primorye Territory].

The paper deals with a clinical evaluation of the results and side-effects of hormonotherapy of 108 patients with prostatic cancer, aged 46-96. Among the most frequent side-effects were: gynecomastia, sexual and neurologic dysfunction. Ziproterone acetate was followed by less frequent side-effects than generic flutamide.

[The concept of screening medicine in oncology].

Screening medicine is a basis of a suggested new concept; it comprises: an evaluation of the basic health fund within the terms of real time; continuity of the medical, ecological, epidemical, congenital and genetic information collected within the medical passport; as well as synthesis of the obtained data and monitoring of patients. The above concept enables a qualitatively new approach to coping with issues of individual health and to rendering a high-quality medical care in oncology.

[Evaluation of efficacy of cyproterone acetate monotherapy in prostatic cancer].

The trial conducted in the Primorsk Regional Cancer Hospital of Vladivostok and P. A. Herzen Moscow Research Cancer Institute studied effectiveness and tolerance of cyproteron acetate (CA) monotherapy and maximal androgenic block (MAB) (CA + surgical or CA + drug castration).

[Synthesis and antibacterial activity of the new 9-aminoacridine, 10,11-dihydro-5H-dibenzo[b,f]azepine, polyfluoro 5,6-dihydro-1,3,5-oxadiazine derivatives].

Screening among 9-aminoacridine, 10,11-dihydro-5H-dibenz[b, f]azepine and polyfluoro 5,6-dihydro-1,3,5-oxadiazine derivatives allowed to isolate compounds with potential antibacterial activity. Schemes of the active compounds synthesis are given. The most important is the estimation of the oxydiazines activity against gram-positive microorganisms including methicillin-resistant staphylococci.

[Effect of enalapril maleate on vascular endothelial function and platelet-endothelial interactions in patients with essential hypertension].

Aim: Evaluation of endothelial function and platelet-endothelial interactions in patients with essential hypertension and dynamics of these changes in the course of treatment with enalapril maleate.

Materials And Methods: The study included 37 patients with essential hypertension and 22 normotensive volunteers. 17 of hypertensive patients received enalapril maleate (enap, KRKA) 5-20 mg/day during the period of 1.

[Effectiveness of pefloxacin in brucellosis].

The clinical efficacy of pefloxacin in the treatment of 51 and 19 patients with acute and subacute brucellosis respectively was studied. It was shown that in a dose of 400 mg twice a day for 15 days pefloxacin provided a rapid regression of the brucellosis clinical signs. By the efficacy it was not inferior to the combination of doxycycline and rifampicin used in the routine doses.

[Multifactor analysis of the effect of pefloxacin on the dynamics of antibody synthesis to EV vaccine fraction 1 and hemagglutinins].

Multifactor analysis of the effect of pefloxacin on the primary immune response to T-independent bacterial antigen (EV vaccine fraction 1) and to T-dependent cellular antigen (sheep erythrocytes) in mice was carried out with the use of a wide variety of the doses and administration times. It was shown that in the doses corresponding to the average therapeutic ones pefloxacin had no affect on the humoral immune response to the EV vaccine fraction 1 antigens while with the use of the subtherapeutic doses the effect was stimulating. When the doses were higher than the therapeutic ones pefloxacin retarded the antibody formation.

[Effect of pefloxacin on luminol-dependent chemiluminescence and leukocyte adhesion].

The in vitro action of pefloxacin on the luminole-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied within a wide range of the concentrations from 0.1 to 100 micrograms/ml. Pefloxacin did not influence the peak values of the chemiluminescence while in concentrations of 0.

[Chemotherapeutic effectiveness of pefloxacin in experimental infections].

High efficacy of pefloxacin was shown in its study on albino mice with experimental infections such as sepsis, pneumonia and peritonitis. In the effective doses administered orally the drug rapidly arrested the clinical signs of the diseases and provided the sanation of the organs and tissues. The broad antibacterial spectrum of pefloxacin substantiated its efficacy in the treatment of purulent septic processes due to gram-negative and gram-positive pathogens, as well as in the treatment of mixed infections.

[Preclinical pharmacokinetics of pefloxacin].

The substance and tablets of pefloxacin mesilate manufactured by the Urals Polytechnical University and the National Research Centre of Antibiotics were studied on rats and dogs with the drug oral administration in single and multiple doses equivalent to the human ones. The bioavailability of the drug was good and its blood levels were efficient for a prolonged period (at least 24 hours) after a single oral administration. No cumulation of the antibiotic after its repeated use was observed.