[Response of central neurons to combined exposure to the neuropeptides angiotensin II and bradykinin].

Angiotensin-II and bradykinin decreased responses of cortical neurons to each other under both successive and simultaneous application in alert rabbits. The observed effects seem to follow complex integration of pre- and postsynaptic influences of these neuropeptides on the cortical neurons.

[Modulating effect of angiotensin II and bradykinin on the mediator sensitivity of central neurons].

Using the methods of extracellular recording of bioelectrical activity and microiontophoresis, the effect of endogenous neuropeptides (angiotensin-II and bradykinin) on the cortical neuronal sensitivity to neurotransmitters was investigated in conscious rabbits. It was found that angiotensin-II and bradykinin modified neuronal responses to neurotransmitters, increasing, decreasing and reversing their mediator sensitivity. The most prominent effect of these neuropeptides was the increase of neuronal responses to acetylcholine and noradrenaline.

[Effect of antibodies to S-100 group proteins on the electrical activity and chemical sensitivity of the cerebral cortical neurons].

The influence of antibodies to proteins S-100 group on electrical activity and chemical sensitivity of rabbit cortical neurons has been investigated by means of extracellular recording and microiontophoresis. It has been found that anti-S-100 increase as a rule spontaneous discharge rate of the neurons, decrease, blockade or invert the neuronal responses to acetylcholine, noradrenaline and glutamate action. It is supposed that proteins S-100 group take part in regulation of eleitrogenic and postsynaptic (primarily glutamate- and GABA-ergic) processes of neural and glial cells in the brain.

[Bradykinin, morphine and naloxone interaction on the sensorimotor cortical neuron level].

In experiments on awake rabbits the effect of bradykinin, morphine and naloxone (applied by means of microiontophoresis) on sensomotor cortical neurons was studied. Bradykinin increased the discharge frequency in the majority of neurons. Morphine inhibited the neuronal activity.