[Effect of the antioxidant OP-6 on some model reactions of the blood coagulation system].

Formation and lysis of fibrin clot were studied in model systems containing antioxidant OP-6, which is concerned with substances of 3-hydroxypyridine class, using viscosimetry, UV- and IR-spectroscopy. The antioxidant was shown to react with fibrin-monomer molecules shifting an equilibrium of the monomer/polymer/aggregate system towards monomer. OP-6 was able to bind heparin reversibly with formation of the dissociation complex.