[The receptor-mediated endocytosis of influenza viruses and low-density lipoproteins by tissue cells].

The experimental data obtained by immunological, immunomorphological, biochemical, and virological methods are presented which substantiate a concept that various strains of influenza virus under study may penetrate tissue cells at sites of high affinity usually meant for low-density lipoproteins (LDLP) providing the cells with cholesterol for construction of outer and inner membranes. A computer analysis of a bank of data on the primary structure of proteins (the package of GENBER programme) revealed significant similarity of amino acid sequences between the area of viral hemagglutinin site attachment to cells and corresponding amino acids comprising apoB LDLP. The presented proofs are a convincing example of virus particles mimicry realized at the molecular level and give new concepts concerning the mechanisms of virus penetration into body cells which are important for the development of a principally new approach to creation of highly effective antiviral compounds.

[The significance of the antihypoxic properties of etimizol in its nootropic action].

The antihypoxic effects of etimizol and other nootropics are analysed on various experimental models of hypoxia and during bicycle ergometric exercise in healthy volunteers. Etimizol was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). The advantage of etimizol as compared to other nootropics with similar action (meclofenoxate, piracetam) is its high effectiveness at a single administration.

[The pharmacology of memory (results and prospects)].

Principal possibilities and limits of using the pharmacological approach for control of memory in studies of neurophysiological and neurochemical mechanisms of learning and memory in humans and animals are reviewed as well as its place in experimental and clinical therapy of memory disorders. Using an unspecific connector aethimizol as a pharmacological probe aided to assess changes accompanying the formation and consolidation of memory traces. The significance of fast and slow bioelectrical brain activity in the memory processing, the role of enzymes involved in transcription and template chromatine activity of the neurons under the effect of drugs on memory and learning, the correlation between time-depending learning and the pattern of RNA synthesis in brain cells, as well as possibilities and pathways of utilization of drugs in the correction of the long-term memory matrix formed by a stable pathological state of the brain, are discussed.

[Effect of etimizol, ethyrasol, and caffeine on the electrical activity of mollusk neurons].

In experiments on Limnae stagnalis neurons, ethymisol increased the AP duration while reducing the trace hyperpolarization and the rate of development of the AP descending phase. Ethymisol (10 mM/1) induced either hyperpolarization of neurons with an increase in membrane resistance or their depolarization (20 mM/1) with a decrease in membrane resistance. A drop in the medium temperature by 2-4 degrees C prevented the hyperpolarization.