[The differentiation of the antigens making up the circulating immune complexes].

A simple method for the detection and analysis of circulating immune complexes (CIC) in specimens of biological fluids is proposed. The method was approved in the examination of patients with chronic infections caused by mycoplasmas and Streptococcus pyogenes L-forms. The method made it possible to diagnose infectious diseases accompanied by the formation of immune complexes and to study the dynamics of the processes of the accumulation and elimination of CIC in the course of the disease.

[The laboratory diagnosis of mycoplasmosis and ureaplasmosis in urological and gynecological patients].

The survey of 630 patients with urogenital pathology, habitual miscarriage and sterility revealed that they were mostly (91-100%) infected with M. hominis and/or U.urealyticum.

[Urogenital mycoplasmosis and Mycoplasma carriage during pregnancy and in inflammatory processes of the genitalia in workers in the electronics industry].

To find out the spread of urogenital Mycoplasma carriership urogenital mycoplasmosis (UGM) among women living and working under similar conditions and making up risk groups with respect to these infections, pregnant women, gynecological patients and clinically healthy women were specially surveyed. As revealed in this survey, UGM and Mycoplasma carriership were found in clinically healthy female workers significantly more often than in other similar groups of the same region. In the group of pregnant women the occurrence of Mycoplasma carriership and UGM reached 90%.

[The persistence of Ureaplasma and its arthritogenic action in the experimental infection of rabbits].

In the experimental intraperitoneal infection of rabbits with U. urealyticum, serotype VIII, transitory polyarthritis with immunomorphological characteristics different from those of human rheumatoid arthritis has been shown to develop in the animals. The pathological process develops simultaneously with Ureaplasma infection.

[Elaboration of clinico-laboratory criteria of the Mycoplasma variants of rheumatoid arthritis in children].

To develop clinical and laboratory criteria for the differential diagnosis of Mycoplasma-induced arthritides in 78 children with documented rheumatic arthritis (RA), a comprehensive study involving microbiological, immunological, and clinical tools has been performed. Some specific signs of the clinical course of Mycoplasma-induced RA have been defined. However, a differential diagnosis of Mycoplasma-induced arthritis may be made on the basis of a comprehensive study of a patient.

[Arthritic pathogenicity of Mycoplasma and Mycoplasma arthritis in humans].

The review deals with Mycoplasma-induced arthritis. It provides the author's own results and the data available in the literature, which suggest that "arthritogenic" Mycoplasma make an etiological contribution to the development of human rheumatic arthritis. It also discusses some well-known and hypothetic mechanisms responsible for the pathogenesis of Mycoplasma-induced arthritis.

[Mycoplasma and Ureaplasma infections in chronic genital inflammatory processes, abortion and infertility].

A total of 43 females including 13 with sterility, 23 with habitual miscarriage and 7 pregnant women with a history of chronic inflammatory diseases were examined by using various tools to detect their Mycoplasma and Ureaplasma infections. The females had been studied for bacterial and chlamydial infections. Forty of them turned out to be infected with M.

[Detection of Mycoplasma infection in the postpartum period].

The comparative results of microbiological and serological testing of parturients with uneventful and complicated course of the postpartum period were presented. The data justified the etiological role of M. hominis and U.

[The infection of monkeys with Ureaplasma urealyticum serovar VIII].

The possibility of modeling chronic infection on monkeys by the injection of the culture of U. urealyticum, serotype VIII, was shown. The infection of monkeys with these microorganisms introduced in a single intraperitoneal injection resulted in the generalization of the process, which was manifested by the persistence and reproduction of the infective agent in the organs and blood of the animals for as long as 6 months (the term of observation).

[Mycoplasma arthritis in man and mechanisms of its pathogenesis].

Possible etiologic contribution of mycoplasma to human rheumatoid arthritis (RA) is supported by their recovery from synovial fluid of RA patients, as well as Mycoplasma antigens and antibodies detection in the bloodstream. The detectability of free antigens of M. arthritidis (Ma) and M.

[Mycoplasma and rheumatoid arthritis in children].

A microbiological and serologic investigation was carried out in 80 children with rheumatoid arthritis (RA) in order to detect Mycoplasma and Ureaplasma as possible causative agents of RA. The antigen of Mycoplasma in question is shown to be detectable in 42.6% of cases more commonly as part of an association of 2 or more species.

[Ultrastructure of the L forms of Streptococcus group B].

The submicroscopic organization of the L-forms of beta-hemolytic streptococci of group B has been studied in the course of their cultivation. The L-forms of group B streptococci differ from those of group A streptococci by a higher growth rate. On the submicroscopic level, the activity of ATP-ase has been revealed on the internal side of the cytoplasmic membrane.

[Detection of microbial variants of Salmonella typhi in the bone marrow of typhoid patients and carriers].

The immunofluorescence test with the use of antisera to S. typhi and its L-forms permits the detection of the infective agent in bone marrow smears. This diagnostic method is particularly important in cases of carrier state in the latent phase and in differential diagnosis.

[Comparative biological characteristics of the L-form of Streptococcus group A and B].

The comparative study of the biological and serological properties of the L-forms of streptococci, groups A and B, has been made. Their morphological similarity on the level of light microscopy has been demonstrated. The use of ring precipitation, gel diffusion, passive hemagglutination, aggregate hemagglutination, as well as the immunoferritin technique, has made it possible to establish the presence of specific antigens in the L-forms of streptococci, groups A and B.

[Antibiotic resistance of revertant cultures of Streptococcus group A and of unclassified streptococci isolated from the blood of rheumatism patients].

Sensitivity of one strain of group A Streptococcus, its L-form and revertant was tested to 7 antibiotics and it was observed that the revertant was highly resistant to beta-lactam antibiotics and lincomycin, tolerant to ristomycin and had a high value of MBcC/MIC for erythromycin and tetracycline. Testing of other analogous revertant strains showed the same results. In streptococcal strains freshly isolated from blood of patients with rheumatism and resistant to some antibiotics there were recorded by electron microscopy heterogeneity of their population and presence in it of a significant number of cells with altered (unevenly thickened) cell walls and cells with microcapsules on the cell wall surface characteristic of the revertants.

[Detection of Mycoplasma antigens (Mycoplasma arthritidis and Mycoplasma fermentans) in the tissues of experimentally infected animals by using indirect immunofluorescence and aggregate-hemagglutination reactions].

The analysis of the results obtained in the detection of mycoplasmic antigens in tissues of infected rabbits by means of the immunofluorescence test and the aggregate hemagglutination test, carried out in parallel, indicates that both these tests are highly specific, while the immunofluorescence test is more sensitive.

[Streptococcus group A L-form survival in mouse peritoneal macrophages].

The survival of the L-forms of group A streptococci in peritoneal macrophages of SHR mice has been studied microbiologically and by the method of indirect immunofluorescence in vitro and in vivo. The phagocytosis of the L-forms, proceeding more actively in vivo, has been found to occur within 1-3 days after inoculation. The preservation of some viable L-forms in macrophages for 6-7 days may apparently facilitate their persistence in the body.