[Evaluation of the efficacy of paracetamol as a component of postoperative combined analgesia in children].

Postoperative pain is one of the most serious problems in patients who have undergone surgical interventions. The paper analyzes the efficiency of various postoperative analgesia regimens in children and shows the high efficiency of paracetamol as a component of combined anesthesia in the postoperative period.

[Mechanisms of early changes in water-electrolyte metabolism in man in various ground-based models of the effects of microgravity].

Analysed was an array of data amassed in 4 series of experiments with simulated microgravity effects (HDT (-6 degrees); dry and suited immersions in horizontal and vertical position). Water-electrolyte turnover in blood and urine and hormonal controls have been under study. It was demonstrated that irrespective of the body axis position relative to the gravity vector in the immersion models, reactions of the active regulation of the water--electrolyte metabolism were noted already within the initial hours, i.

[Water-salt metabolism and its hormonal regulation studied in the 2nd joint Soviet-French space flight].

During a 25-day space mission of French cosmonaut on board Mir station, the joint Soviet-French Czecho-Slovak experiment "Minilab" has been conducted in order to evaluate a fluid-electrolyte metabolism status and its hormonal control at different flight stages and early postflight. In cosmonaut venous blood was drawn twice, and 24-hour urine samples were collected on mission Days 5 and 19. With the aid of Plasma-02 equipment the blood plasma and urinary samples were treated, frozen and maintained aboard the station.

[Calcium pooling by plasma and extra-plasma buffer systems: effects of prolonged hypokinesia].

Healthy test subjects were intravenously injected with calcium solutions during ambulatory activity and after 100-day exposure to head-down tilt. It was demonstrated that different mechanisms were involved in maintaining ionized calcium at a constant level and that their contribution changed after the tilt study. It was also shown that the capacity of extra plasma pool was decreased, kinetic characteristics of the Ca2+ binding reaction were modified, and responses of mineralotropic hormones to induced hypercalcemia were enhanced.

[Dynamics of prostaglandin contents and several indicators of lipid metabolism in man exposed to prolonged hypokinesis].

Nine healthy test subjects divided into Group A and Group B were bed rested (with the head down at -5 degrees) for 370 days. Group A subjects exercised from the beginning of the study while Group B subjects began exercising only 120 days after. During the study prostaglandins PGE and PGF2 alpha in serum and fatty acids in serum and erythrocyte membranes were measured.

[Status of water-electrolyte homeostasis and the systems of hormonal regulation during 237-day space flight].

On mission days 216-219 two crewmembers collected urine and recorded their food and water consumption during three days on end. The cosmonaut-physician withdrew blood samples from the vein and finger. In addition, he made venipuncture to himself and drew blood.