[Dynamics of microsymbiocenoses of upper respiratory tract in normal state and in pathology].

Aim: Study of features of interaction of bacteria in microsymbiocenoses of upper respiratory tract in dynamics in individuals with various state of health: healthy individuals, individuals after tonsillitis and bacteria carriers.

Materials And Methods: Modification of pathogenicity factors (hemolytic, lecitovitellase, lysozyme and anti-lysozyme activity) in intermicrobial interactions of 226 strains of microorganisms isolated during quintuple analysis of upper respiratory tract biocenoses of examined individuals was studied. A hierarchical structure of each microbiocenosis was built based on the data obtained, and its temporal dynamics evaluated.

[Study of nasal and tonsillar mucosal microbiocenoses as one of the health indices].

The qualitative and quantitative compositions of nasal and tonsillar mucosal biocenoses were studied in healthy individuals and patients with chronic tonsillitis as an ecological criterion for assessing the stability of biocenosis and human health. The qualitative composition of tonsillar mucosal biocenosis turned out to be steady-state both in health and disease. The human nasal mucosa showed itself as an indicator system.

[Evaluation of malignancy of squamous cell lung cancer by clinico-morphological, immunohistochemical and prognostic study of tumor markers].

An immunological study was carried out in 127 cases of surgical treatment of squamous cell lung cancer. Cryostat sections were used to identify markers of proliferation (Ki-67 and topoisomerase IIalpha), apoptosis (p53 and CAS) and intercellular adhesion (E-cadcherin). It was shown that Ki-67 and topoisomerase IIalpha proliferation rates and CAS expression may be interpreted as additional factors of squamous cell cancer aggressiveness while E-cadcherin expression--as a favorable prognosticator.

[Correlation of proliferation, apoptosis, angiogenesis and metastasizing in various histogenetic types of pulmonary cancer (an immunohistochemical investigation)].

Surgical material from 157 patients with lung carcinoma was studied. Immunohistochemical detection of the following oncomarkers was performed: Ki67, p53, CD34, CAS, Topoisomerase II alfa, nm23 protein, E-cadherin. The existence of association between proliferation, tumour cell apoptosis and formation of vessels in the tumour stroma is established.