[Medical and social importance of Acute Myocardial Infarction Register for major industrial enterprises workers (exemplified by Siberian Chemical Works)].

Prevalence of acute myocardial infarction does not differ between groups that were or were not subjected to long radiation of low intensity. Creation and completing of the Acute Myocardial Infarction Register helps to objectively monitor situations, to form risk groups, to provide purposeful measures for lower mortality with and occurrence of acute myocardial infarction.

[Epidemiological studies as an instrument for assessment of society welfare and quality of medical service (examplified by of analysis of myocardial infarction morbidity)].

Dynamics of incidence of myocardial infarction among adult (older than 20 years) population of Seversk in 1998-2006 was studied according to WHO program "Myocardial Infarction Register" updated in concordance with criteria of Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction (2002). Incidence of myocardial infarction in the studied population had steady tendency to growth with equal contribution of such components as first and recurrent myocardial infarction what was related to progressive aging of population. Hospital myocardial infarction mortality showed steady tendency to decline evidencing for improvement of quality of medical service.

[The risk of arterial hypertension development in Siberian Group of Chemical Enterprises personnel].

to study risk factors of arterial hypertension (AH), their significance for AH pathogenesis in atomic power plants employees occupationally exposed to long-term ionizing radiation in a "low" dose range (cumulative external radiation doses in the range up 1 Sv). The case-control study was carried in the cohort of workers aged 40-50 ever employed at the Siberian Group of Chemical Enterprises (SGCE) between 2003-2005. 970 persons were examined by standardized epidemiological methods.

[Risk factors prevalence for cardiovascular diseases among atomic power industry enterprises personnel].

Unlabelled: A selective cross-sectional study based on Regional Medico-Dosimetric Register was carried out in some Siberian Group of Chemical Enterprises (SGCE) workers (aged 40-50) with the aim of studying the most important risk factors prevalence for cardiovascular diseases development. 2010 persons examined with the use of standardized epidemiological methods made up 32.6% of total SGCE personnel aged 40-50.

[Regional medico-dosimetric register (RMDR) is a model for evaluation of long-term "low" dose ionizing radiation effects on Siberian group of chemical enterprises main production personnel].

Medico-dosimetric register is an optimal model of epidemiological studies on evaluation of ionizing radiation effects. Regional medico-dosimetric register (RMDR) is a system of interrelating information blocks including data on Siberian Group of Chemical Enterprises (SGCE) personnel. At present SGCE personnel and Seversk residents RMDR database includes information on 138496 persons, 65538 of which are SGCE workers.

[Novel diagnostic possibilities of transesophageal stress echocardiography with electrical atrial pacing].

In order to develop simple technique of combination of transesophageal echocardiography (TEE) and transesophageal pacing, to create algorithm and protocol of transesophageal stress-echocardiography, and to study possible complications and methods of their elimination we examined 39 subjects (mean age 50 +/- 7.2 years) with suspected ischemic heart disease (IHD), 22 patients with arterial hypertension, 11 patients with episodes of ischemic changes on 24 hour ECG. In 11 patients with high blood pressure (BP) and 2 patients with frequent ventricular extrasystoles veloergometry was contraindicated, and in 3 patients veloergometry was not informative due to complete left bundle branch block.

[Clinical and epidemiological analysis of possibility of acute myocardial infarction development in personnel of radiation dangerous plants].

According to the data of cohort and to the "case-control" studies, dynamics of an acute myocardial infarction (AMI) morbidity during the period 1998-2002 and role of radiation factor in AMI development among personnel of radiation dangerous plants (by the example of Siberian Group of Chemical Enterprises (SGCE) exposed to a long-term impact of ionizing radiation in the range of "low" doses) were being carried out. It was determined that in personnel of the main production (working in contact with IR sources) the gradient increase of AMI morbidity was registered during the study period. Personnel of the main production in comparison to personnel of support production (correlating age, sex and examination level) have statistically significant increase of standardized relative risk coefficients of AMI development.

[Preclinical diagnosis of cardiovascular diseases in workers engaged into industries with radiation danger].

The authors presented results of single-stage cross study of randomized select from a cohort of long seniority workers of isotope separation plant in Siberian Chemical Enterprise, with studies of inflammation markers, vascular and platelet hemostasis, serum lipid parameters, calculated atherogeneity coefficient, homocysteine levels. Serum atherogeneity coefficient and inflammation markers levels (fibrinogen, C-reactive protein) could be considered as the most informative laboratory indicators of underlying cardiovascular diseases in individuals without ischemic heart disease. Among a list of standard inductors of platelet aggregation, collagen and epinephrine should be considered preferential.

[Evaluation of homeostatic disorders induced by radiation exposure].

Possibilities of correction and prophylaxis. The authors presented results of study covering workers of radiation-dangerous plants of Siberian Chemical Enterprise, who underwent long-term exposure to outer and inner radiation in "low" doses range during the occupational activity. Target-systems for radiation effects were proved to be lipid peroxidation and antioxidant defence systems, cell energy metabolism--severity of disorders in which is correlated with degree of radiation exposure.

[The role of transesophageal dopplerographical assessment of coronary reserve in coronary sinus in diagnosis of hemodynamically significant left coronary artery stenoses].

Aim: To assess the role of estimation of coronary reserve in coronary sinus by transesophageal doppler during dipyridamole stress test for diagnosis of hemodynamically significant left coronary artery stenoses.

Material: Patients with angiographically proven left coronary artery stenoses (n=29) and 25 healthy volunteers.

Methods: Coronary reserve was calculated as 1) ratio of peak to basal diastolic coronary flow velocity (V(p)CR), and 2) ratio of volume coronary blood flow velocity before and during hyperemia (VBF CR).

[Predictive value of echocardiography in infectious endocarditis].

182 patients with infectious endocarditis (IE) were examined for correlations between valvular bacterial vegetations and IE activity, course, results of bacteriological and morphological findings. 81 of the patients had primary IE, 71 patients had secondary IE which had developed in uncorrected valvular heart disease, in 30 patients secondary IE had developed after surgical correction of rheumatic heart disease. It is shown that echocardiographic detection of bacterial vegetations does not determine IE severity, course and outcome.