[A role of additional methods of examination in neurological diagnostics].

The current work covers the question of the additional methods of examination in neurology. The special accent is put on electroneuromyography (ENMG). The actuality and importance of knowledge of ENMG basic principles for the neurologists are shown.

[Carpal tunnel syndrome: diagnostics and conservative treatment].

The Carpal tunnel syndrome is the most frequent entrapment neuropaphy of human. The Article is dedicated to diagnostics and conservative treatment this pathology. The early diagnostics and in time fixed treatment prevents the progress of the disease, raises the quality of life and allows to avoid surgical procedure.

[Subacute inflammatory demyelinating polyradiculopathy associated with Epstein-Barr viral infection: a clinical case].

The clinical case of treatment a patient for subacute inflammatory demyelinating polyradiculopathy associated with Epstein-Barr viral infection is presented. It is showed that the period of rehabilitation after the indicated disease lasts long enough. It requires the differentiated approach in acute and recovery treatment period with using of different rehabilitation measures.

[Intracardiac hemodynamics in patients with isolated chronic obstructive pulmonary disease and coronary heart disease].

Analysis of intracardiac hemodynamics is presented in patients with isolated stage II, III and IV chronic obstructive pulmonary disease (COPD) in the period of exacerbation and in those having COPD with concomitant coronary heart disease (stable angina of functional class II). Retrospective evaluation included 100 medical histories. Color Doppler echoCG was performed and parameters of systolic and diastolic function of both ventricles measured.

[Contribution of signals and antisignals in the mutational spectrum of the td-intron insertion site].

The insertion sites of the td-intron were studied. It was found that tetranucleotides W-30A-29W-28Y-27, V-19B-18W-17A-16 and A11W12A13W14 predominantly occur at normal sites (signals), and tetranucleotides Y-27W-26M-25G-24, V7B8W9A10 and Y15W16M17G18 occur more frequently at defective sites (antisignals). It was shown that antisignals make the site defective, by blocking its signals.

[Averaging results of site recognition can increase the accuracy of annotating the human genome].

A systemic approach is proposed, which makes it possible to increase the accuracy of recognition of functional sites in arbitrary DNA sequences. The approach is based on the Central limit theorem and consists in the averaging of a large number of recognitions of a particular site. To obtain a rather large number of recognitions within the framework of conventional methods of recognition, consensus, and frequency matrix, 20 novel oligonucleotide alphabets were used.