[Leukocyte-modulating and antioxidant activity of blood serum and bronchoalveolar lavage fluid in the course of the decompression period of long crush syndrome].

We studied leukocyte-modulating activity (LMA) and antioxidant activity (AOA) of blood serum and bronchoalveolar lavage fluid (BAL) in the course of a postcompression period of crush syndrome (CS) in rats. CS was modelled by compression of the left back leg of the animal with metal vice (compression area 5 cm2, duration 4 hours). In CS decompression, LMA of both the serum and BAL was high.

[Protein metabolism impairment in long-term crush syndrome].

Experiments on Wistar rat males modelled crush syndrome (CS). Stability of blood protein composition in rats undergoing CS decompression was found. This reflects activation of protein synthesis in the defense systems of the body due to stress reaction to CS.

[The specificity of lipid metabolism in hereditary arterial hypertension induced by stress].

Studies of lipid metabolites in the plasma and lymph of rats with hereditary arterial hypertension induced by stress (HAHIS) showed decreased plasma and lymph pool of total cholesterol (TC) in comparison with normotensive Wistar rats. In HAHIS animals, TC concentration in the lymph was lower than in the plasma. The concentrations of triglycerides and free fatty acids in the plasma and lymph of hypertensive animals were virtually the same and higher than in normotensive ones.

[The effect of acute hypoxia on the fatty acid composition and lipid peroxidation of the liver microsomal membranes and blood plasma in rats with different resistances to oxygen deficiency].

The experiments in rats showed the changes in the fatty acids composition of lipids of hepatic microsomal membranes and lipids of blood plasma after acute hypobaric hypoxia to depend on individual resistance of animals to oxygen deficiency. In highly resistant rats the content of unsaturated fatty acids and lipid peroxidation activity in blood plasma increased. In low-resistant rats similar changes occurred in lipids of hepatic microsomal membranes.

[Aldosterone and electrolyte content in blood and myocardium of rats after single physical load in acute alcoholic intoxication].

It is shown that acute alcoholic intoxication causes essential changes of aldosterone content and balance of electrolytes in blood plasma of Wistar rat males. The SPL test revealed the inadequate reaction in the mineral-corticoid function of the adrenal glands in the rats with acute alcoholic intoxication. The method of the free choice of the load by the experimental rats is the most optimal way to assess.

[Contents of aldosterone and electrolytes in blood plasma and the myocardium of rats after single physical exertion during acute alcoholic intoxication].

It was proved in experiments with male Wistar rats that acute alcohol intoxication caused significant changes in electrolytes balance in blood plasma and myocardium remaining for a long time after ethanol injection. SPL test makes it possible to reveal inadequate reaction of blood plasma aldosterone in alcohol injected rats. This fact may be considered as the fact of involving extracardiac component of compensation of myocardial functional insufficiency conditioned mainly by electrolyte unbalance.

[The role of the Ca2(+)-blocking effect of alcohol in the genesis of ischemic myocardial damage].

The experiments on Wistar male rats with induced myocardial infarction have studied the role of Ca-blocking effect of acute ethanol administration in ischemic injury of myocardium. It has been established that acute alcohol intoxication led to destabilization of adaptive processes in ischemic myocardium.