[Antiradical and NO-inhibiting activities of bet-hydroxy(ethoxy) derivatives of nitrous heterocycles].

The antiradical and NO-inhibiting activities of beta-hydroxy(ethoxy) derivatives of nitrous heterocycles (3-hydroxypyridine, 5-hydroxybenzimodazole, and 6-hydroxy(alkoxy)-benzothiazole) have been studied. The antiradical activity has been studied using a homogeneous hydrophilic chemiluminescent system, and the quenching constants (Ki) have been determined. For the most reactive compound, 4-methylthiobenzimidazolyl-3-hydroxypyridine, Ki = 4.

[Primary and secondary metabolism of winter wheat under cold hardening and treatment with antioxidants].

The content of saccharides and phenolic compounds (including flavonoids and lignin) and the activity of L-phenylalanine ammonia-lyase (PAL, EC 4.3.1.

[The use of implantable cardioverter-defibrillators in patients at high risk of sudden cardiac death].

We have reviewed literature on contemporary views on sudden cardiac death (SCD), detection of category of patients belonging to the group with high risk of SCD, and methods of SCD prevention. Randomized studies on assessment of efficacy of implantable cardioverter-defibrillators (ICD) for primary and secondary prevention of SCD have been reviewed in detail as well. We also present experience with clinical management of patients with ICD in the Main Military Clinical Hospital named after N.

[Clinical efficacy of permanent cardiac pacing in patients with bradysystolic forms of disturbances of cardiac rhythm and conduction].

From 1996 to 2002 primary implantations of pacing systems because of bradysystolic disturbances of cardiac rhythm and conduction had been carried out in 311 patients. Indications were disturbances of atrioventricular conduction in 168 and sick sinus syndrome in 143 patients. According to type of permanent pacing patients were divided into 3 groups: with single-chamber ventricular on demand pacing (VVI, n=215), with single-chamber atrial pacing (AAI, n=39), and with dual-chamber pacing (DDD, n=57).

[Effect of cardiac resynchronization therapy on quality of life of patients with chronic heart failure].

Aim: To study quality of life of heart failure patients who underwent cardiac resynchronization therapy.

Material And Methods: Cardiac resynchronization devices were implanted to 27 consecutive patients (69.7+/-11.

[A synthesis of tritium-labeled olanzapine].

A synthesis of olanzapine, 2-methyl-10-(4-methyl-1-piperazinyl)-4H-thieno[2,3-b][1,5]benzodiazepine was carried out, and the conditions for its tritium labeling were optimized, to get a tritium-labeled olanzapine preparation with molar radioactivity of 12 Ci/mmol.

[Interaction of nonelectrolytes, the derivatives of 5-hydroxybenzimidazole, with erythrocyte membrane].

The method of spin probe and scanning electron microscopy were used to study the effects of some new synthetic antioxidants and bioregulators, the derivatives of 5-hydroxybenzimidazole, on the membrane structure and morphology of erythrocytes. Analysis of EPR spectra and electron micrographs revealed that the derivatives with various side substituents affect the membrane structure and shape of erythrocytes in a concentration-dependent manner, the effect correlating with the hydrophobic properties of the side derivatives. It was shown that all the compounds in the concentration range 1.

[The action of benzimidazole derivative preparations on the formation of DNA-protein cross-links in the UV irradiation of chromatin].

Effect of benzimidazole-derivatives on the DNA-protein binding formation was studied after UV-radiation of chromatin. These derivatives were shown to protect chromatin from UV-induced DNA-protein binding formation. Structural analog contained two aminomethyl residuals sensibilized additional binding formation in chromatin.

[Method of calculation of the allowance for deviation from the fixed center-to-center spacing in eyeglasses].

The author provides evidence for a method of calculating the allowance for deviation from the prescribed spacing on centres in the spectacles. Shows that values of the limit deviations obtained by the method described is compared very favourably with those employed today.

[Functional significance of the left adrenal vein and the gonadal veins].

Owing to the investigation of changeability variants of the left adrenal, anastomosis of the inferior diaphragmatic and ovarian (testicular) veins--tributaries of the human left renal vein, three variants in inflow of the left adrenal vein in comparison to the left ovarian (testicular) vein have been revealed. In the first variant, that occurs in 70% of cases, the left adrenal vein flows into the left renal vein by 15 cm more medially from the ostium of the ovarial (testicular) vein. The second variant occurs in 11%.

[Preclinical study of the safety of the new Soviet tranquilizer gindarin].

The Soviet plant tranquilizer gindarin (an isoquinoline series alkaloid I-tetrahydropalmatine) isolated from the tubers of Stephania glabra Miers was subjected to a preclinical study. As regards the toxicity measured during a single administration to the laboratory animals, gindarin may be classified with moderately toxic substances. Daily intragastric administration of gindarin to rats in doses of 20 and 60 mg/kg for 3 months is likely to give rise to the changes in functions of the CNS, liver and blood.