[Plasma Renin Activity and Potential of Indapamide Retard to Improve Control of Hypertension].

Purpose: to study plasma renin activity (PRA) as a predictor of antihypertensive response to addition of diuretic to combination of angiotensin- converting enzyme inhibitor (ACEI) and calcium antagonist (CA).

Material And Methods: The study included 72 patients (39% men, mean age 62.0 ± 8.

[Visit-to-visit blood pressure variability: clinical and prognostic significance].

The phenomenon of variability of blood pressure (BP) was studied for a long time, but recently it has received increased attention, with the focus shifted from short-term BP variability, estimated at daily monitoring for clinical blood pressure variability from visit to visit, which can be regarded as one of the indicators quality control of blood pressure with prolonged treatment. In light of the recent years of clinical data from visit to visit BP variability seems a promising new target for antihypertensive therapy.

[The state of carotid arteries in young men with arterial hypertension].

Purpose: To study elastic properties of carotid arteries in young men with arterial hypertension (AH).

Material And Methods: We examined men aged 18-25 years (mean 21.1+/-0.

[Efficacy of fixed combination amlodipine/valsartan in hospitalized patients with hypertensive disease].

Efficacy and tolerability of fixed amlodipine/valsartan combination was studied in 86 patients with hypertensive disease hospitalized in departments of general internal medicine or cardiology. All patients had indications for antihypertensive therapy and were randomized either to fixed combination amlodipine/valsartan (n=43) or to therapy which corresponded to the hospital formulary (n=43). Correction of antihypertensive therapy was performed by treating physician at daily rounds.

[Echocardiographic assessment of myocardial fibrosis in young men with arterial hypertension and different types of left ventricular remodeling].

In order to study structural functional characteristics of myocardium including parameters of myocardial fibrosis according echocardiography data in men with various levels of arterial pressure (AP) we examined 215 men aged 18-25 (mean 21.1+/-0,1) years with history of elevated AP at casual measurement. AP phenotype (normotension, stable arterial hypertension [AH], unstable AH) was determined on the basis of multiple measurements of clinical AP and 24 hour AP monitoring.

[Achievements and problems of modern trials of antihypertensive drugs].

Most important value of lowering of substantially elevated arterial pressure (AP) for improvement of outcomes in patients with arterial hypertension (AH) was convincingly confirmed by large truly placebo controlled randomized clinical trials (RCT) with the use of mainly diuretics, and/or beta-adrenoblockers in the 60-80ths. Later comparative RCT confirmed equal antihypertensive efficacy of 5 main drug classes relative to AP level in brachial artery. In this review we discuss merit of auxiliary class-specific properties of antihypertensive agents potentially affecting prognosis besides AP lowering.

[Characteristics of central pulse wave in young men with various phenotypes of arterial pressure].

In this work we compared parameters of central arterial pressure (AP) on the basis of analysis of pulse wave in young men in dependence of AP phenotype determined by repetitive clinical measurements and 24 hour AP monitoring (24HAPM). Comparison of characteristics of central pulse wave was carried out in 12 men with normal AP, 36 men with arterial hypertension (AH) according to clinical measurements and 24HAPM, and 17 men with white coat hypertension (WCH). Mean age was 21.

[Phenotypes of arterial pressure in young men].

Aim: To study with the use of repetitive clinical measurements and 24-hour arterial pressure (AP) monitoring phenotypes of AP in young men aged 18-25 years with history of elevation of AP at accidental determination.

Material And Methods: We examined 194 young men (mean age 21.1+/-2.

[Essential hypertension, dementia, and antihypertensive therapy in geriatric patients].

The review summarizes the current views on the pathogenesis of dementia and the significance of blood pressure levels for its development. The present status of the prevention of cognitive disorders and dementia is detailed in the use of antihypertensive therapy: there are the data of prospective cohort studies of the impact of antihypertensive therapy on the risk of dementia, the results of placebo-controlled studies in the groups of elderly and senile patients with a history of cerebrovascular complications, and the data of meta-analyses of studies. As for cognitive function, the effects of different classes of the currently available antihypertensive agents, such as diuretics, calcium antagonists, angiotensin-converting enzyme inhibitors, and angiotensin II type 1 receptor antagonists, are analyzed.

[Disproportionately high left ventricular myocardial mass in patients with arterial hypertension].

Background: Increase of myocardial mass of left ventricle (MMLV) to a greater extent than required by hemodynamic load by elevated arterial pressure (AP) is reflected in concepts of " disproportionately " high (DH) MMLV and resistant to antihypertensive treatment LV hypertrophy (LVH).

Aim: To study in patients with arterial hypertension (AH) frequency of DH MMLV and factors associated with it.

Material And Methods: Patients (n=170, 70 men, age 57.

[Antihypertensive treatment compliance and obstacles to its improvement. Results of Russian program ARGUS-2].

Aim: To study barriers made by the patients for adequate treatment of arterial hypertension.

Material And Methods: The ARGUS-2 trial was made in 15 centers of 13 cities of Russia. Anonymous questionnaire survey covered 1298 patients (796 outpatients and 502 inpatients).

[Recommendations on arterial hypertension 2007: text, context, and speculations].

At the Congress of the European Society on Arterial Hypertension (AH) in June 2007 in Milan were presented Second European Recommendations on AH traditionally attracting huge attention. Novel Recommendations appear to be revision of the 2003 variant and in distinction to recommendations of WHO are oriented to more high economical potential of European Countries. Positions contained in the novel version in recommendations reflect contemporary knowledge about AH in connection with this their educational but not directive or prescribing character is distinctly designated.

[Central arterial pressure: a necessary parameter for assessment of cardiovascular risk and efficacy of antihypertensive therapy].

Most of large controlled randomized trials have not revealed superiority of "new" over "old" antihypertensive drugs and posed a question of value of surrogate criteria for comparison of various treatment regimes. Data of ASCOT-CAFE trials allow to assume that estimation of central blood pressure (BP) opens novel perspectives in this direction. Most affordable methods of noninvasive measurement of central BP are radial artery applanation tonometry with subsequent computer transformation of peripheral to central pulse wave, and carotid artery applanation tonometry.

[Problems of a physician-patient interaction and control of arterial hypertension in Russia. Main results of scientific-practical program ARGUS-2].

Objective: To study the problems of physician-patient cooperation, patient- and physician related barrieres to target blood pressure (BP) achievement and to demonstrate improvement of BP control with indapamide SR 1.5 mg, when given to patients remaining uncontrolled while receiving antihypertensive therapy without thiazide diuretics (TD).

Methods: The trial Improvement of Arterial Hypertension Control in High-Risk Hypertensive Patients (ARGUS-2) run in 15 Russian centres during the year 2006.