[Gluttony, obesity and the metabolic syndrome in the context of the "seven deadly sins". Historical-theological, literary and art, mass media, political, philosophical, medical-psychological and geriatric aspects of the problem].

In this pape different aspects of problem of obesity are analysed.

[Gastroenterologist diagnosting left atrial myxoma in patient with gastroesophageal reflux disease].

The authors presents the clinical case of the left atrial myxoma diagnosed by gastroenterologist in patient with gastroesophageal reflux disease.

[Endotoxin (LPS) in the pathogenesis of atherosclerosis].

Recent data on the processes underlying atherogenesis indicate the significant role of endotoxin (lipopolysaccharide - LPS) of the intestinal microflora in the development of vascular lesions. This paper summarizes the literature and material results of their research on the participation of LPS gramnegativnyh bacteria in the initiation and progression of atherosclerosis. We prove that the LPS of gram-negative bacteria interact with TLR4, triggers cytokine cascade with the subsequent formation of atheroma.

[Geriatric pharmacotherapy].

The number of changes in bodies and fabrics connected with aging or illness processes increases. These changes mention all processes of pharmacokinetics and pharmacodynamics. With the increase it slows down processes of absorption, distribution, a metabolism and medical product deducing.

[Detection of endotoxins of Gram-negative bacteria on the basis of electromagnetic radiation frequency spectrum].

Method of Gram-negative bacteria endotoxins detection on the basis of their own spectrum of electromagnetic radiation frequency was developed. Frequency spectrum typical for chemotype Re glycolipid, which is a part of lypopolysaccharides in the majority of Gram-negative bacteria, was used. Two devices--"Mini- Expert-DT" (manufactured by IMEDIS, Moscow) and "Bicom" (manufactured by Regumed, Germany)--were used as generators of electromagnetic radiation.

[Non-steroidal anti-inflammatory drugs and tramadol in the treatment of osteoarthrosis deformans in patients with arterial hypertension].

The prohypertensive effect of non-steroidal anti-inflammatory drugs (NSAIDs) can be manifested by the decreased efficiency of antihypertensive therapy. The tactics of their differential use in relation to the its effect on blood pressure (BP) in patients with osteoarthrosis (OA) and arterial hypertension (AH) has not been developed for the most effective and safe therapy. In this connection, it is extremely urgent to study the comparative safety of used NSAIDs as to their prohypertensive effect and to work out the management of patients with AH and OA.

[Endotoxin-induced injury to the endothelium].

Literature and own data on endotoxin- induced injuries to endothelium are reviewed. It is shown that endotoxin can cause, hyperactivation of granulocytes, activation of complements, local endothelial injuries and some increase of vascular cell wall permeability, oxidation of low-density lipoproteins (LDL) and LDL-LPS complexes, binding of LPS with high-density lipoproteins (HDL) and some decrease of HDL ability to bind cholesterol, stimulation of endothelial and smooth muscle cell replication in local injuries to vessel wall. Low doses of endotoxin were found in blood plasma and on granulocytes surface in healthy and sick subjects.

[The effects of eiconol in elderly patients with non-insulin-dependent diabetes mellitus].

A nutritional additive eikonol containing polyunsaturated fatty acids omega-3 was given for a month (8 g/day) to correct vascular complications in 60 patients with non-insulin-dependent diabetes mellitus (NIDDM). Eikonol-treated NIDDM patients with diabetic retinopathy, polyneuropathy, angiopathy of the legs combining with arterial hypertension exhibited a reduction in the levels of total cholesterol, triglycerides, low and very low density lipoproteins cholesterol, a rise in concentrations of high density lipoproteins cholesterol. Blood pressure went down, peripheral vascular resistance and microhemocirculation improved.

[Experience in the use of eiconol (a complex of unsaturated fatty acids) in non-insulin-dependent diabetes mellitus].

Cardiovascular disease is the principal cause of morbidity, functional disability and fatal outcomes in patients with non-insulin-dependent diabetes mellitus (NIDDM). The results of administration of eikonol, food additive containing omega-3 unsaturated fatty acids, for 3 months were analyzed for 60 elderly NIDDM patients with ischemic heart disease. A single administration of eikonol leads to a decrease in accumulation of intracellular cholesterol by 15%.