[Results of comprehensive conservative treatment of patients with no-option chronic limb-threatening ischaemia].

Aim: The study was aimed at comparing efficacy of conventional conservative therapy and comprehensive treatment including a plasmid VEGF-165-gene therapy drug in 'no-option' chronic limb-threatening ischaemia with different prevalence of trophic ulcers and infection during a 1-year follow-up period.

Patients And Methods: A total of 101 patients (54% being men and 46% women, mean age 69 years) with 'no-option' chronic limb-threatening ischaemia underwent comprehensive conservative treatment. They were subdivided into 4 groups according to the WIFI classification: WIFI 130 (n=38), 131 (n=23), 230 (n=16), 231 (n=24).

[Immediate results of conservative treatment of patients with unreconstructable critical limb ischaemia and trophic changes].

The purpose of the study was to comparatively assess efficacy of using agents belonging to the group of prostaglandin E1 in comprehensive conservative treatment of patients with unreconstructable critical limb ischaemia and trophic changes by the frequency of major amputation, amputation-free survival, and total mortality by combinations of the WIfI classification during a 6-month follow up period. Our retrospective multicentre study enrolled a total of 109 patients, including 60 men and 49 women, with a mean age of 70±7.3 years.

[Differentiated approach to treatment of decompensated lower limb ischaemia with the use of the WIFI classification system].

In the present article, the authors substantiate the necessity of subdividing a heterogeneous cohort of patients presenting with Fontaine-Pokrovsky grade IV critical limb ischaemia into subgroups with the aim of making an appropriate therapeutic decision and predicting the outcome. We also translated into the Russian language the WIfI classification system developed by the Society for Vascular Surgery (2014) in order to predict limb loss and feasibility of performing revascularization. This is followed by comments on the classification, accompanied by examples of own clinical case studies.

[REMOTE 3-YEAR RESULTS OF APPLICATION OF <> WAYS OF REVASCULARIZATION IN PATIENTS WITH CHRONIC ISCHEMIA OF LOWER EXTREMITIES].

There are several ways of <> revascularization such as revascularizated osteotrepanation of shinbone and lumbar sympathectomy (LS) for treatment of patients with chronic ischemia of lower extremities. They appeared to be sufficiently effective for the patients with II stage of the disease. Patients with critical ischemia (III stage) had persistent positive results after lumbar sympathectomy during 3-year period only in 33% of cases and using revacularized osteotrepnation - 46%.

[Efficacy of using VEGF165 gene in comprehensive treatment of patients with stage 2A-3 lower limb chronic ischaemia].

The authors share their experience in treating a total of 100 patients presenting with stage 2A-3 chronic lower limb ischaemia according to the classification of Pokrovsky-Fontain (the clinical group was composed of 75 patients and the control group comprised 25 subjects), in whom it was impossible to perform surgical revascularization. The clinical group patients received in addition to the conventional vascular therapy local intramuscular injections of Neovasculogen (plasmid genetic construction containing human gene VEGF165) at a course dose of 2.4 mg.

[Therapeutic angiogenesis in treatment of patients with chronic obliterating diseases of lower limb arteries].

The authors share their experience gained in realization of the concept of "therapeutic angiogenesis" by means of the first Russian gene therapeutic agent Neovasculogen in comprehensive treatment of patients with stage II-III chronic obliterating disease of lower limb arteries (CODLLA) according to the Pokrovsky-Fontain classification. A total of 45 patients were treated. The findings were assessed and analyzed depending on the stage of chronic lower limb ischaemia.

[Specific medical strategy for aneurysm of the abdominal aorta].

An analysis of results of treatment of 323 patients with aneurysm of the abdominal and thoraco-abdominal parts of the aorta was made for the period from 1995 through 2010. The patients' age was within the limits from 45 to 88 years and was 67.2 +/- 6.

[The nearest and remote results in treatment aneurysms of the abdominal aorta and the main arteries].

In the modern literature are taken widely up questions of medical tactics at an aneurysm of abdominal aorta (AA) depending on its sizes, presence of signs and presence of risk factors. The purpose of work was studying current aneurysm illnesses in various arterial parts, developments of optimum tactics of conducting patients and its influence on the remote results of operative treatment. Into research have entered 51 patient, suffering aneurism of an aorta, it branches and other main arteries.

[Diagnosis and surgical treatment of ischemic lesions of the viscera in elderly patients with aorto-femoral atherosclerosis].

During the period from 1991 to 2000 161 patients with atherosclerosis of the aortic-femoral zone, aged over 60, underwent scheduled treatment in the vascular surgery department of the clinical regional hospital of the city of Yaroslavl. In 62 (38.5%) patients different pathology of the visceral arteries was revealed according to the diagnostic analysis.

[Diagnosis and treatment of pseudoaneurysms after reconstructive interventions with the use of synthetic prostheses].

The author analyses an experience with treatment of 43 patients with false aneurysms of anastomoses after reconstructions in the aorto-femoral zone (5.8% of all the patients operated on). A combination with an infection of the prostheses was registered in 9 patients, two of them had aneurysms of the proximal aorto-prosthetic anastomosis.

[Diagnosis and treatment of abdominal aortic aneurysm in elderly and older patients].

83 patients over 60 years with abdominal aortic aneurysms (AAA) were treated from 1991 to 2000. 87.9% patients were men.