[The natural peptide geroprotector antiarhythmic action].

The research of biological activity of peptide geroprotector Slavinorm on the basis of calf aorta extract was conducted in experimental models of hypertension and chloride-calcium arrhythmia. The research results showed that in experimental model of arrhythmia in rats induced by pituitrin administration, intraventricular and intramuscular introduction of Slavinorm in therapeutical dose had caused to leveling of hypertension symptoms. That was expressed in normalization of blood pressure characteristics, body weight, heart and kidney weight.

[Depressive frustration at vascular diseases of a brain in patients of elderly and senile age].

According to inspection of 206 patients of 60 years old and elder on the basis of neurologic department of the Geriatric Center of Republican Hospital No 3 high prevalence of depression of small and average degree in the persons of advanced age suffering from cerebrovascular diseases is revealed. To estimate the expressiveness of depression the Hamilton's scale including 17 parameters was used.

[All-cause mortality among men of elderly and senile age depending on day of week, a season and changing to daylight saving time for a 13-year period].

To study the all-cause mortality among men of elderly and senile age depending on day of week, month of year, a season, changing to daylight saving time, prospective supervision over 1067 men of 60 years and upward for a 13-year period was conducted. The all-cause mortality depending on transition into daylight saving time was counted for March and October and compared to indicators of April and November accordingly. The all-cause mortality rate had made 1668,5 on 1000.

[The role of partial myocardial revascularization in treatment of elderly patients with ischemic heart disease].

One of the main difficulties in cardiology is how to correctly choose the volume and method of treatment in elderly patients with ischemic heart disease. 165 elderly patients with IHD were included into the study. 83 patients received partial myocardial revascularization by PTCA and stenting and 82 patients were on the conservative medical treatment.

[Characteristics of myocardial revascularization in aged patients with ischemic heart disease].

One of the main difficulties in cardiology is how to correctly choose the tactickof surgical or interventional treatment in elderly patients with IHD. It is widely known that cardiovascular diseases are the main cause of mortality and invalidization all over the world. Atherosclerosis, by WHO data, takes the leading place in morbidity of industrial countries population.

[Na K ATPase activity and pulmonary hemodynamics in the development of arterial hypertension].

A total of 116 subjects with borderline hypertension, 67 relatives of normotensive probands and 29 relatives of hypertensive probands were examined. The activity of Na,K-ATPase in the red blood cells and pulmonary hemodynamics were studied by kinetocardiography. The normotensives with a family history of essential hypertension and subjects with borderline hypertension were found to have elevated pulmonary systolic pressure.

[Status of the venous system and pulmonary circulation at early stages of development of arterial hypertension (clinico-experimental comparisons)].

The study was undertaken to examine 116 patients with borderline arterial hypertension (BAH), 67 normotensives without a family history of hypertensive disease (HD), and 29 normotensive relatives with HD. The hemodynamics of systemic and pulmonary circulations were investigated. For comparison, the functional activity of the portal vein was studied in spontaneously hypertensive rats of different age.

[HLA antigens in patients with different forms of arterial hypertension].

The authors analyze the frequency of HLA [correction of HIA] antigens in 121 male patients with borderline arterial hypertension and in 60 patients with hypertensive disease, stage II. The frequency of HLA [correction of HIA] antigens in these patients was compared with their frequency in the male population of Leningrad inhabitants (858 healthy donors). Patients with borderline arterial hypertension showed a characteristic increase of the frequency of B16, B18 CW4 antigens.

[The activity and properties of Na,K-ATPase in the erythrocytes and the Na-pump inhibitor in the plasma of subjects with borderline arterial hypertension].

The activity and properties of Na,K-ATPase in erythrocytes and their membrane preparations (ghosts) from 34 subjects with borderline hypertension and 21 normotensive controls were studied. The Na,K-ATPase activity was found to be by 43% lower as compared to control group. No changes in the Na,K-ATPase activity were revealed in the ghosts of borderline subjects.

[Disordered lipid metabolism in patients with arterial hypertension].

The author studied the lipid metabolism in 121 persons with borderline arterial hypertension, in 36 persons with normal arterial pressure without hereditary aggravation for hypertensive disease. It was established that persons with borderline arterial hypertension showed an increase of the level of triglycerides and atherogeneity as compared with normotensive persons without hereditary aggravation for hypertensive disease. Normotensive relatives of patients with hypertensive disease revealed changes of the lipid metabolism analogous with borderline arterial hypertension.

[The echocardiographic signs of left ventricular hypertrophy in persons with borderline arterial hypertension and hypertensive disease and their relatives].

Altogether 122 persons underwent echocardiographic studies. All the persons examined were distributed into 5 groups: group 1 comprised healthy persons without hereditary aggravation as regards essential hypertension (EH); group 2 included healthy persons with aggravated heredity as regards EH; group 3 was made up of persons with borderline arterial hypertension; group 4 of persons with labile EH; group 5 of persons with stable EH. Early appearance of the signs of left ventricular hypertrophy was recorded in persons with hereditary aggravation as regards EH.