Publications by authors named "Iu S Malov"

Aim: To study acid-base balance (ABB) of the organism, gastric secretion of hydrocarbonate (HCO3-) in ulcer patients and to examine their relationships.

Material And Methods: ABB in capillary or venous blood before and after losec and famotidine treatment and gastric secretion of HCO3- were studied in 72 patients with ulcer.

Results: It was found that patients with gastroduodenal ulcer have metabolic, less frequently hypercapnic acidosis with suppressed gastric secretion of HCO3-.

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Acid-base balance was studied in 60 ulcer patients in exacerbation and after treatment with losek and blockers of H2-histamine receptors. In exacerbation, all the patients had acidosis of metabolic or respiratory type. Losek changed blood pH insignificantly, and one acidosis type changed for the other.

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Aim: The study of alkaline gastric secretion in health and disease and its changes in response to blockers of H2-histamine receptors.

Materials And Methods: The trial enrolled 74 patients with duodenal ulcer (DU), 28 patients with chronic gastric (CG) and 16 healthy controls. The secretion was studied initially, in administration of ranitidine, in stimulation with hydrochloric acid.

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At the division of general therapy N 1 of the Kirov Military Medical Academy a version of automated training system was elaborated for the IBM AT/386 users of MS DOS operational system. The knowledge text control was carried out during the lessons at the display classroom equipped with Wyse-85 terminals ("Wyse Technology Company"), DEC VT 220 regimen, and connected up to PC IBM AT/386 which works in multiterminal function. Application of text control has shown that the volume of knowledge had increased up to 82-90%, but it was right only for the groups where the methodics of classes with application of the results of text controls was strictly adhered.

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Studies into the content of nonspecific defense factors, secretory and serum immunoglobulins in blood and biological fluids (saliva, gastric juice, duodenal contents) in patients suffering from peptic ulcer have demonstrated significant changes in local and general immunity. Exacerbation of the disease was marked by a decrease of the titer of complement, C3-component of complement, and lysozyme level. At the same time there was an increase of the concentration of secretory immunoglobulins and immunoglobulins in blood serum and external secretions.

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The effect of cholinolytics in combination with antacids, belomet, solcoseryl and enterodes on humoral immunity was evaluated in 134 ulcer patients. Elevated levels of salivary secretory IgA and blood IgG, IgA, lowered blood IgD exhibited in ulcer exacerbation. Antibodies to oligopeptides isolated from the serum of ulcer patients occurred in 80.

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Serum levels of secretory IgA were measured in 66 patients with aggravation of peptic ulcer versus 52 healthy subjects. IgA concentrations in the patients were found elevated, the rise being dependent on the ulcer site, standing and severity of course. Treatment-induced decline of the ulcer exacerbation was accompanied by a fall in IgA levels.

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An important role in the protection of the gastric and duodenal mucosa is played by bicarbonates. Gastric secretion of bicarbonates was examined in 42 patients with gastroduodenal pathology. Basal secretion of bicarbonates by the stomach was approximately the same (0.

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The paper considers common phase-specific trends in hypothalamic-hypophyseal-gonadal function observed in duodenal ulcer. Progesterone and estradiol levels as well as testosterone/estradiol relationship correlated with frequency of duodenal ulcer recurrences.

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Factors of unspecific defense and immunological state were evaluated in 520 patients with ulcer disease. It was established that these patients revealed disorders of excessive release into the internal medium of the body of food antigens, in particular partially split proteins. The latter induce the immune response.

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Systemic and local humoral immunity and nonspecific defense factors were investigated in 88 patients with duodenal peptic ulcers and 18 patients with gastric ulcers. In acute conditions, nonspecific defence was depressed and blood IgG level was increased in peptic ulcer patients. An increase in complement titre, C3 and lysozyme, and a decrease in IgG were recorded after treatment, although normal levels were never attained.

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Fifty-four healthy subjects and 56 peptic ulcer patients were examined for blood serum polypeptides, their toxicity and antigenicity. It was discovered that in the peptic ulcer patients, the blood polypeptide content was 1.5-3-fold higher than in healthy subjects.

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