[Photo oxidative reactions of psoralens and their role in therapy of dermatoses].

Psoralenes (furocoumarins) in combination with ultraviolet (UV) A radiation (320-400 nm) are used in the treatment of vitiligo, psoriasis, cutaneous T-cell lymphoma and other skin and autoimmune diseases (PUFA therapy). The mechanism of psoralene-photosensitive modification of biologically significant molecules, such as DNA, protein unsaturated lipids, antioxidants, etc. is considered in the paper.

[The therapeutic efficacy of tigazon in treating dermatoses].

Forty patients with various dermatoses (psoriasis, ichthyosis, Darier's disease, discoid lupus erythematosis) were followed-up over the course of treatment with tigason, an aromatic retinoid. The effect was satisfactory in the majority of patients. Side effects were recorded in 16 cases.