[Genetic variants of CYP1B1 and WDR36 in the patients with primary congenital glaucoma and primary open angle glaucoma from Saint-Petersburg].

In 32 patients with primary congenital glaucoma (PCG), a search for mutations in the myocilin (MYOC), cytochrome P450B1 (CYP1B1), and WDR36 genes was performed. The Q368X mutation in myocilin gene, typical of the patients with adult-onset primary open-angle glaucoma (POAG), was not detected in the PCG patients. Screening of the CYP1B1 introns 2 and 3 for the presence of mutations in PCG patients revealed only six DNA polymorphisms, including IVS1-12ntT>C (g.

[Comparative characteristics of current tonometric methods].

Corneal thickness is known to have a considerable impact on the results of applanation tonometry. A Pascal dynamic contour tonomer (SMT Swiss Microtechnology AG) the readings of which are not affected by the properties of the cornea has recently come into the world market. The objective of the investigation was to comparatively evaluate Pascal, Goldmann, and Maklakov tonometers.

[Comparative assessment of various methods for diagnosis of diabetic macular edema].

This study compared the sensitivity and specificity of various methods for diagnosing diabetic macular edema. It included patients with types 1 and 2 diabetes mellitus and healthy volunteers. In addition to standard ophthalmological examination, the authors performed computed perimetry with subthreshold and threshold brightness, Amsler's test, optical coherent tomography, retinal confocal tomography, and fluorescence angiography.

[Implantation of porous polytetrafluoroethylene orbital inserts: complications. Communication 2].

The purpose of the study was to analyze the pattern and frequency of complications following 230 implants of porous polytetrafluoroethylene (PTFE) orbital inserts. The total frequency of the complications to be treated was 7.4%.

[Implantation of porous polytetrafluoroethylene orbital inserts: techniques and outcomes. Communication 1].

This paper presents the outcomes of 230 primary, advanced, and secondary implants of polytetrafluoroethylene orbital inserts manufactured by the closed joint stock company "Nauchno-Proizvodstvennyi Kompleks (Scientific-and-Production Complex) "Ekoflon" (Saint Petersburg). The duration of a follow-up was 6-36 months (mean 15.9 +/- 037 months).

[Mutations and polymorphisms in the genes for myocilin and optineur in as the risk factors of primary open-angle glaucoma].

A collection of DNA samples obtained from primary open-angle glaucoma (POAG) patients from St. Petersburg was analyzed for single-strand conformation polymorphism (SSCP) to reveal sequence variants in exon 3 of the myocilin gene (MYOC/TIGR) and in exons 4 and 5 of the optineurin gene (OPTN), where most of the mutations revealed worldwide are located. The Q368X mutation (c.

[Present-day trends in the development of nonpenetrating surgery of glaucoma].

The so-called nonpenetrating surgeries have been, during the recent years, used on an expanding basis in patients with open-angle glaucoma. The paper focuses on their evolution from sinusotomy, suggested by M.M.

[Retinoschisis. 1. Diagnosis, classification, examination methods].

Extensive clinical data (595 patients) were made use of to work out a clinical classification and to isolate 2 groups of patients, i.e. one with primary retinoschisis and the other with secondary retinoschisis.

[Effectiveness of treating peripapillary geographic choriopathy].

The results of treatment of 77 patients (127 eyes) with peripapillary geographic choriopathy (PGC) were generalized. The drug therapy gave positive results in 45.4% of cases, relative stabilization was noted in 54.

[Radionuclide imaging of lacrimal duct in health and disease].

Dacryoscintigraphy is a perspective method for examination of the lacrimal system function. It has many advantages over other methods (functional tests, roentgenography, and computer-aided tomography) and notably improves the diagnostic potentialities of examination of the lacrimal function. The technique and results of the method are discussed.

[Decreased content of non-heme iron in the blood of patients with peripheral tapetoretinal abiotrophy].

Measurement of non-heme iron in the sera of patients with peripheral tapetoretinal abiotrophy aged 10-72 years with stages I-IV of the disease showed a statistically significant (26-30%) decrease of this parameter in comparison with healthy controls. Total iron-binding capacity of the serum was unchanged. The results are discussed with regard for previous reports about changed iron homeostasis in animals with hereditary retinal degeneration (Campbell rats) and the role of iron in the development and formation of nervous tissues.

[Combined injuries of the eye by shots from gas barrel guns for self defense].

Combined (mechanical and chemical) injury to the eye was induced by shooting from gas guns of 8 and 9 mm caliber to the eyes of biomannequins from a distance of 50 cm. Mechanical particles released during shot (intact and partially burnt gunpowder and other components of the shell) may be carrying a chemical on their surface, which, when getting into the wound channel of ocular membranes, diffuses to the adjacent tissues and injures them. These data necessitate comprehensive studies of injuries to the eyes caused by shots from gas barrel guns, which are to be carried out by clinical ophthalmologists, toxicologists, and forensic medics in order to identify all the possible consequences of injuries caused by irritants, accurately assess the duration of the posttraumatic process in the victims, and evaluate bodily injuries.

[A new device for measuring blood pressure in the ophthalmic artery: automated vacuum ophthalmodynamometer].

A new vacuum ophthalmodynamometer is suggested. When measuring the orbital artery pressure, ophthalmic tone elevation is achieved via creating vacuum in suction cup located on the sclera. Changes in the design helped improve the accuracy of measurements and their safety, as against the known analogs.

[Gamma resonance velocimetry of the eye].

A new method for the registration of ocular orbital pulse in humans is suggested, based on the nuclear gamma resonance effect. In normal subjects the velocity of the corneal movement over the period of a cardiac contraction is under 0.3 mm/s, and the mean amplitude of corneal transposition is 21.