[Study of the relations between prazosin administration schedule for patients with subacute myocardial infarction and the type of central hemodynamics based on pharmacokinetic data].

The model-independent pharmacokinetics and hemodynamics were studied in 48 patients (35 males and 13 females; mean age, 60.0 +/- 1.3 years) with primary myocardial infarction of various sites.

[The pharmacokinetics and the concentration-and-effect relationship of prazosin in patients at the beginning of the subacute period of myocardial infarct complicated by the development of heart failure].

The pharmacokinetics of prazosin was studied in 16 patients in the early subacute period of myocardial infarction complicated with heart failure following a single and 10-day administration. The increase of the half-life of the drug (6.6 +/- 1.

[Prazosin pharmacodynamics and pharmacokinetics in patients with myocardial infarct complicated by heart failure in the subacute period].

Central hemodynamic parameters were monitored by invasive procedures (pulmonary arterial catheterization), and prazosin kinetics following the administration of a single 5 mg dose were determined in 69 patients with subacute myocardial infarction, complicated by heart failure. The response to prazosin was dependent on pretreatment hemodynamic parameters and differed between patients with early and manifest heart failure. There was a correlation between the peaks of hemodynamic change and drug concentration.