[Outpatient care of young invalids with locomotor defects].

Aim: The study of somatic health in patients with locomotor defects (infantile cerebral paralysis, meningoencephalocele, myodystrophy) to reveal abnormalities in function of the principal systems and organs of these patients.

Materials And Methods: The examination covered 93 students of Moscow institute for invalids suffering from locomotor defects (mean age 18.2 +/- 0.

[Detection of risk factors for hemodynamic dysadaptation under physical loading by data of genetic studies (the beta-adrenoreceptor blockade test) (Part 3)].

Examinations in 28 pairs of twins who were studied by bicycle ergometry during a "pure" graded exercise and an exercise during oral administration of anapriline have shown that the functional features of the heart make some contribution to cardiovascular implementation of the "pure" graded exercise. When given exercise and anapriline, energy processes play a role in its implementation. It is suggested that exercise + anapriline will cause substantial metabolic changes which can be essential in cardiac decompensation if exercise is not limited in the use of beta-blockers.

[Detection of risk factors for hemodynamic dysadaptation under physical loading by data of genetic studies (echocardiography data) (Part 2)].

Examination in 28 pairs of twins who were studied by echocardiography just after their performance of exercise (Stage I) and at the peak of effects produced by oral anapriline (Stage II) have shown that at rest such parameters as end-systolic volume, ejection fraction, relative changes in the internal dimension of the left ventricular cavity during a cardiac cycle, show moderate-to-high genetic predisposition. At the same time, a persistent contribution of heredity to myocardial contractility is found only for end-systolic volume when the conditions of the examination were changed. The lesser extent to which contractility parameters had hereditable signs, the more intensively they varied under different conditions.

[Detection of risk factors for hemodynamic dysadaptation under physical loading based on data from genetic studies (Part 1)].

Twenty-eight pairs of unisexual healthy twins were examined during exercise, on anapriline or their combination. The twin technique of calculating the additive component of blood pressure and catecholamine levels was used in each of the terms of the examination. beta-adrenoceptor blockade was found to be a highly potent environmental factor under whose influence both resting and exercise blood pressures were not provided by inheritable regulatory mechanisms.