[Effects of stimulation and blockade of D2-dopaminergic receptors on behavior In gonadectomized male rats].

The present study aims to perform the comparative assessment of stimulation and blockade for D2-dopaminergic receptors in depression-like behavior in male rats with deficiency of androgen hormones. Two weeks after surgery, GDX rats began 14 days of treatment with vehicle, a low dose of testosterone propionate (0.5 mg/kg, s.

[Pecularities for action of combined administration of NAN-190 and ketanserine with low dose of 17β-estradiol on depression-like behavior in prenatally stressed ovariectomized rats].

The aim of the present work was to perform a comparative analysis of 5-HT(1A)- and 5-HT(2A/2C)-receptors blockade effects on depression-like behavior of the adult ovariectomized (OVX) female offspring at estrogen deficiency delivered from their prenatally stressed mothers. The adult prenatally stressed OVX female offspring were chronically (during 14 days) treated by 5-HT(1A)-receptors antagonist--NAN-190 (0.1 mg/kg, s.

[Influence of stimulation and blockade of α4β2 nicotinic acetylcholine receptors on learning of female rats in basic phases of ovary cycle].

The present work was devoted to the comparative analysis of α4β2 nicotinic acetylcholine receptors (nAChRs) in learning/memory processes during ovary cycle in the adult female rats. RJR-2403 (1.0 mg/kg, i.

[Effect of alpha4beta2 nicotinic acetylcholine receptor agonists and antagonists on learning in female rats during different phases of ovary cycle].

The present work was devoted to the comparative analysis of alpha4beta2 nicotinic acetylcholine receptors (nAChRs) in learning/ memory processes during ovary cycle assessed in adult female rats. RJR-2403 (1.0 mg/kg, i.

[Effects of 8-OH-DPAT and m-CPP on depression-like behavior in prenatally stressed ovariectomized rats treated with low dose of 17beta-estradiol].

The present work was aimed at a comparative estimation of the effect of stimulation of 5-HTIA and 5-HT(2B/2C) receptors on depression-like behavior in adult ovariectomized (estrogen-deficient) female offspring from prenatally stressed (PS) mothers. PS ovariectomized female rats were treated for 14 days of with the vehicle, a low dose of 17beta-estradiol (5.0 microg/rat, s.

[Chronic administration of RJR-2403 in combination with low-dose of 17beta-estradiol corrects passive avoidance learning in ovariectomized rats].

The aim of this work was to study the effect of stimulation or blockade of Na7-cholinoreceptors with a low dose of 17beta-estradiol on the passive avoidance performance and behavior in the open-field test in adult ovariectomized (OVX) female rats. Agonist of Na7-cholinoreceptors RJR-2403 (1.0 mg/kg, i.

[Influence of agonist and antagonist Nalpha7-cholinoreceptors on active avoidance learning and gonadal hormones levels in ovariectomized female rats].

The aim of this work was to study the influence of co-administration of agonist and antagonist of Nalpha7-cholinoreceptors with low dose of 17beta-estradiol on dynamics of acquisition and retention in active avoidance test, on the behavior in the "open field" test, as well as tropic and gonadal hormones levels in ovariectomiczed female rats. Antagonist of Nalpha7-cholinoreceptors - RJR-2403 (1.0 mg/kg, i.

[Co-administration of NAN-190 with low dose of testosterone propionate improves passive avoidance performance in rats with androgen deficiency].

We have studied the effect of stimulation or blockade of the 5-HT(1A) receptors on the passive avoidance performance and open-field test behavior in gonadectomized (GDX) male rats of middle age treated with a low dose of testosterone propionate. of The 5-HT(1A) receptor agonist 8-OH-DPAT (0.05 mg/kg, s.

[Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions].

The present work was aimed at a comparative investigation of the effects of chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.

[Effects of new amino acid derivates of dopamine on anxiety-like behavior].

This study was aimed at a comparative analysis of the effects of new amino acid derivatives of dopamine (IEM-2111, IEM-21122, IEM-2123, IEM-2126) on anxiety-like behavior in rats. The behavioral effects of the dopamine-like substances were evaluated under conditions of acute and chronic experiments. In acute experiment, a single dose of substances was administered 45 min prior to the behavioral testing of animals.

[Stimulation of D1-receptors improves passive avoidance learning of female rats during ovary cycle].

The involvement of D1-receptors in learning/memory processes during ovary cycle was assessed in the adult female rats. SKF-38393 (0,1 mg/kg, i.p.

[Characterization of depression-like behavior in prenatally stressed female rats during ovary cycle].

The aim of the present work was a comparative analysis of dynamics of depression-like behavior in prenatally stressed and non-prenatally stressed female rats in the key phases of the ovary cycle. It was found that non-stressed female rats demonstrated high level of depression-like behavior in proestrous phase as compared to the diestrous phase, whereas these rats showed low level of depression-like behavior in estrous phase in Porsolt's test. On the contrary, there were no significant differences in extent of depression-like behavior between prenatally stressed rats in the diestrous and proestrous, although in the phase of estrous in these animals an increase in level of depression-like behavior was noted.

[Stimulation of D2-receptors improves passive avoidance learning in female rats].

The involvement of D2-receptors in learning/memory processes during ovary cycle was assessed in the adult female rats. Quinperole (0,1 mg/kg, i.p.

[D2-type dopaminergic receptors and anxiety-depression-like behavior in female rats].

Results of a comparative study of the effects of chronic administration of the D2-receptor agonist quinperole (0.1 mg/kg, i.p.

[Behavioral effects of ketanserine in prenatally stressed female rats].

Comparative study of the effects of chronic administration of 5-HT(2A/2C)-receptors agonist (m-CPP, 0.5 mg/kg, i.p.

[Prenatal stressed female rats develop stable anxious and depressive state in experimental model of post-traumatic stress disorder].

The effects of immobilization stress from 15th to 19th days of gestation on pathological state development in the model of post-traumatic stress disorder in adult female offspring were studied. The results showed that prenatally stressed female rats as well as control rats demonstrated long-term high anxiety and hypersensitive glucocorticoid feedback in the stress-restress model. Enhanced depressive-like behaviour was found only in prenatally stressed females.

[Administration of quinpirole with 17beta-estradiol in low doses corrects active avoidance performance in ovariectomized female rats].

The influence of D1/D2 types of dopaminergic receptors on the dynamics of acquisition and extinction of active avoidance performance and the behavior of ovariectomized female rats has been studied in the open field test. The DI-type dopaminergic receptor agonist SKF-38393 (0.1 mg/kg, i.

[Involvement of some subtypes of 5-HT2-receptors in affective behavior in female rats].

The present work was devoted to the comparative analysis of influence of chronic administration of 5-HT(2B/2C) receptors agonist - m-CPP (0,5 mg/kg, i.p.) and 5-HT(2A/2C) receptors antagonist - ketanserine (0,1 mg/kg, i.

[Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats].

The influence of the chronic (14-day) administration of 5-HT1A receptor agonist 8-OH-DPAT (0.05 mg/kg, s.c.

[Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats].

A comparative analysis of the influence of chronic administration of the 5-HT2B/2C receptor agonist, m-CPP (0.5 mg/kg, i.p.

[Experience of joint administration of neuromidin and ovestin for correcting cognitive disorders in females with hypoestrogenic syndrome].

The aim of the present study was to assess the efficacy of combined administration of neuromidin and ovestin in low doses for pharmacocorrection of cognitive disorders in women after total ovariectomy. The obtained results are indicative of a pronounced efficacy of the proposed combined therapy for the pharmaco-correction of cognitive disorders as compared to the standard hormone replacement therapy in women with hypoestrogenic syndrome. This is confirmed by significant decrease of mental impairments on the conventional (Mattis dementia) clinical rating scale and in neuropsychological tests.

[Comparative efficacy of selective serotonin reuptake inhibitors in young prenatally stressed female rats].

Effects of the chronic administration of selective serotonin reuptake inhibitors (SSRIs) fluoxetine (daily 5.0 mg/kg, p.o.

[Effect of new polyprenol drug ropren on anxiety-depressive-like behavior in rats with experimental Alzheimer disease].

Influence of the chronic administration of ropren (Trademark)--a plant preparation based on the neutral fraction of extract of spruce and pine needles--on affective status in male rats with amyloid peptide (Abeta(25-35)) induced amnesia has been studied. Ropren was administered per os in a dose of 8.6 mg/kg for 28 days.

[Effect of agonist and antagonist of 5-HT(1A) receptors on learning in female rats during ovarian cycle].

The involvement of 5-HT(1A) receptors in learning/memory processes during ovary cycle was assessed in the adult female rats. 8-OH-DPAT (0.05 mg/kg, s.

[Participation of D(1)-receptors in anxiety-depression-like behaviour in female rats for ovary cycle].

The present work was devoted to the comparative analysis of influence of chronic administration of D(1)-receptors agonist - SKF-38393 (0,1 mg/kg, i.p.) and D1-receptors antagonist - SCH-23390 (0,1 mg/kg, i.