[A rapid method for determining the cellular subpopulation status of the human immune system].

The suggested rapid method is based on a modification of the microlymphocytotoxic test. The results of a single-stage variant of microlymphocytotoxic test with monoclonal antibodies to T and B cell determinants and subclasses thereof and to NK cells were similar to the results of standard immunofluorescent method, this giving grounds for clinical use of rapid immunodiagnostic method.

[Frequency distribution of HLA phenotypes, haplotypes and alleles in ethnic groups of Taĭmyr and Chukotka].

HLA typing data of two little populations living in Tajmyr peninsula (Dolgans and Nganasans) and Chukotka peninsula (Chukchas and Chuvantses) were presented. Our data were compared with the International standard distribution of class I HLA antigens in orients and its distribution in orients who live in the Asian part of Russia. Indexes of genetic distribution and genetic likeness were calculated.

[Significance of the changes in the level of expression of HLA antigens on the surface of T lymphocytes in differential diagnosis of joint diseases of different nature].

The authors calculated sensitivity, specificity, informativeness and diagnostic coefficient and relative risk of the joint index reflecting the degree of T-lymphocytes activation in patients with RA as compared with healthy persons and patients in the control group.

[Study of the changes in the expression of histocompatibility antigens on the monocyte surface in the evaluation of the macrophage component of the immune system in rheumatoid arthritis].

Peripheral blood monocytes from 23 healthy persons and 25 RA patients were studied by cytohistochemistry, indirect immunofluorescence and cytophotometry to reveal interrelationship between cellular function of the system of mononuclear phagocytes and the expression of HLA-complex antigens in health and in RA. An increase in the phagocytic and metabolic activity of circulating monocytes was shown to be associated with a degree of the activity of an inflammatory process. A decrease in the level of the expression of HLA antigens class I was established in parallel with the rearrangement of the numerical ratio of cells expressing low and high levels of class II HLA-molecules.