[Effectiveness of pathogenetic treatment of arterial obliterative diseases of the extremities].

The authors studied the activity of blood serum amine oxidase in patients with atherosclerosis obliterans and endarteritis obliterans. It was found that amine oxidase activity exceeded the normal value. 2.

[The effect of HBO therapy in the early postoperative period on the late outcomes of "compelled" suturing in perforated gastroduodenal ulcers].

Under study were long-term results of forced suturing of perforated ulcers of the stomach and duodenum in 96 patients. It was shown that in patients who were subjected to hyperbaric oxygenation in addition to medicamentous treatment at the early postoperative period excellent and good results were obtained two times more often and there was 1.5 time less amount of bad outcomes as compared with patients who were not given HBO therapy.

[The prognosis of the course of endogenous intoxication in emergency surgery].

On the basis of an analysis of 256 patients with diffuse peritonitis, destructive pancreatitis, mechanical jaundice and purulent cholangitis and complex investigations it was established that the degree of clinical manifestations of endointoxication corresponded to a definite degree of disorders of the central nervous system. The most adequate indices of the course and prognosing the toxic process are thought to be the level of the leukocytic index of intoxication, the prothrombin index, the degree of monocytopenia and proteinuria. Their dynamics reflects changes of the concentration of toxic intermediary metabolites and main characteristics of electron paramagnetic resonance of blood plasma.

[The structure of endogenous intoxication in acute intestinal obstruction and the methods for its correction].

The structure of endogenic intoxication by products of the intermediate metabolism was studied in 32 patients with intestinal obstruction. The leading components of the endogenic intoxication are: acetone, propionic aldehyde and ethanol. In cases of a complicated course of the intestinal obstruction the operative treatment by traditional therapy in the postoperative period proved to be insufficient.

[Serum amine oxidase activity and the methods of its correction in patients with arterial occlusive diseases of the extremities].

The article presents results of examination of blood serum ++amine oxidase++ in 78 patients with obliterating diseases of the extremity arteries. It was found that enzyme activity was dependent on the form and stage of the disease. The data obtained were used for the examination and medicamentous correction of the enzyme activity.

[Endogenous toxemia in pancreatic necrosis of alcoholic etiology].

Operation for pancreonecrosis was carried out in 197 patients, in 52 (26.4%) of them the disease was of alcoholic etiology. The disease was marked by severe clinical manifestations with the development of respiratory, hemodynamic, and peritoneal syndromes and their complications, and by psychic disorders.

[Indicators of the sympathetico-adrenal system in patients with peritonitis after hyperbaric oxygenation].

Hyperbaric oxygenation was used in 32 patients with acute peritonitis and terminal phases of the disease. Changes in the sympatho-adrenal system indices in the blood and excretion of catecholamines with urine during HBO course were investigated. The general pool of adrenaline and noradrenaline in the blood was shown to decrease, their excretion with urine to increase.

[The structure of endotoxemia in peritonitis and means of eliminating it].

An examination of 43 patients has revealed 11 toxic compounds of intermediary metabolism (aldehydes, methylizocyanide, ethanol, aceton etc.) whose concentration in blood became several tens times higher. Their accumulation was most considerable at the decompensation phase.

[Importance of the indices of immunity for predicting the course and assessing the effectiveness of the treatment in acute suppurative lactation mastitis].

The examination of 47 patients with acute purulent lactation mastitis and 14 patients with the resulting sepsis has shown a decreased level of nonspecific resistance factors. Generalization of the purulent process is characterized by disturbed humoral and cellular links of immunity. The dynamic research of immunity factors can give an estimation of the effectiveness of the chosen treatment and prognosis of possible complications.

[The kallikrein-kinin system in acute peritonitis and methods of correcting its disorders].

In experimental fecal peritonitis in 140 albino rats the kallikrein-kinin system was shown to undergo the following changes: its inhibition during the first day was followed by an activation on the second day and inanition on the third day. Under conditions of hyperbaric oxygenation the normalizing effect on the kinin system was observed during two days. The application of salicylates against the background of HBO was shown to enhance the normalizing effect which lasted for three days.

[Endogenous toxicity in acute hepatic failure and ways of eliminating it].

The structure of causes of the endogenous intoxication in 39 patients with acute hepatic insufficiency is studied. Eleven toxic compounds of an organic nature were found responsible for genesis fo the disorders and outcomes of acute hepatic insufficiency. Possible use of hemosorption and hyperbaric oxygenation for the elimination of toxic products is analysed.

[Effect of hyperbaric oxygenation on delayed hypersensitivity and antibody formation in patients with peritonitis].

The inhibition of the formation of hypersensitivity of delayed type to staphylococcus, Proteus, blue pus bacillus and Escherichia coli was found in patients with peritonitis given complex treatment including hyperbaric oxygenation, against the background of stimulation of the antibody formation to these bacteria. The level of staphylococcal alfa-antitoxin in the blood serum remained substantially lower than that of healthy people whether the treatment included HBO or not. The data obtained show the expediency of early use of HBO in patients with peritonitis.

[Hyperbaric oxygenation in the complex treatment of complicated forms of acute suppurative mastitis].

HBO was used in the complex of curative measures in 57 patients with complicated course of acute purulent mastitis. Its positive effect upon the external ventilation, general hemodynamics, reduced intoxication, correction of the secondary immune insufficiency and healing of the wounds was shown.

[Blood plasma kinin system status in mechanical jaundice and means for its correction].

The state of the kinin system in mechanical jaundice and possible ways for its normalization were analysed on the basis of clinico-experimental observations. In 32 patients with postoperative hepatic insufficiency developed against the background of mechanical jaundice a considerable activation of the kinin system was detected which was found to have a direct correlation with the severity of the disease. In experiments on 185 albino rats with model of mechanical jaundice during 40 days a comparative analysis of the state of the kinin system in the initial state, under conditions of hyperbaric oxygenation (HBO) and when using kontrikal and sodium salicylate against the background of HBO was made.

[Activity of T- and B-system lymphocytes in generalized purulent infections].

The comparison of the results obtained in the study of blood samples taken from 37 septic patients and 60 healthy persons has revealed that general purulent infection is accompanied by a drop in the percentage and absolute content of T-lymphocytes in the peripheral blood, by a rise in the level off D-lymphocytes, by a considerable increase in the number of O-cells. At the same time the patients with general purulent infection show a change in the functional activity of the B-system of lymphocytes, which is manifested by a decrease in the amount of IgM and IgG, an increase in the titers of antibodies to staphylococci, strain 209p. These data suggest that in general purulent infection profound disturbances occur in the immune system of the body.