[Anti-HIV effect of soy products and possibility of their usage as medicinal and prophylactic nutrition].

An anti-HIV effect of soy products (emulsion, flour) has been revealed in vitro experiment. The unique properties of biologically active components of soy products made from the whole soybeans justify their usage in HIV/AIDS treatment as an additional treatment and prophylactic nutrition.

[Soy products for dietary treatment of children with erosive-ulcerative lesions of the alimentary tract].

The usage of soy products for dietary treatment of children with erosive-ulcer lesions of alimentary tract brings positive clinical dynamics, normalization of colon function and protein metabolism, acceleration of erosive defects repair, immune status correction. The obtained results justify inclusion of soy products into duodenal pathology treatment--especially when accompanied by protein deficiency.

[Development of encephalitis in modeling of acute hemorrhagic stroke--a new variant of a somatic complication].

We studied immunological and morphological changes in rat brain in an acute period of experimental hemorrhagic stroke (HS). The latter was induced mechanically by the method of A. N.

[Role of enteral feeding mixture based on soy in correction of immune status of patients with burn wounds].

The authors have studied the immune status of patients with burn wounds, which had early received to their complex therapy of burn disease an additional enteral feeding based on soy suspension. All populations of immunocompetent cells have been revealed to be activated, especially T-helper lymphocytes taking part in reparative processes, antibody production, synthesis of anti-inflammatory cytokines, thus contributing to regenerative processes taking place in burn wounds, speeding patients' recovering.

[Effect of additional enteral feeding based on soy suspension on burn wound healing].

Early involvement in complex therapy of burn disease an additional enteral feeding based on soy suspension has enhanced host defenses, improved cell and humoral immunity indices, decreased a number of complications (mainly infectious), stimulated regenerative processes taking place in burn wounds thus speeding patients' recovering.

[Pathomorphological aspects and outcome of influenza virus and Klebsiella pneumonia in the experiment].

Mice infected with K. pneumoniae against the background of prior introduction of influenza A/Hong-Kong/68 virus developed focal bronchial pneumonia with leukocytic exudate that started resolving at day 10 of the experiment. At about this time and later there appeared in the lungs spots of apparent proliferative processes characteristic of productive inflammation.

[Pathomorphological changes in the uterine wall in gestosis].

With the purpose of studying a morphological substrate of the uterine contractile function disorder in gestosis, an investigation was conducted designed to study biopsy specimens of the uterine wall having been taken during the cesarean section in 80 parturient women. The womb of those parturient women having mild and severe gestosis complicated by uterine inertia (40 observations) or premature dethachement of the normally situated placenta (8 cases) was studied together with that of controls (32 cases). The indentified micro-circulatory disturbances and alterative changes in the myometrium structures in gestosis are regarded as one of the generalized blood circulation disorders, hemostasis (dissaminated intravascular blood coagulation) and systemic abnormalities of metabolism presenting as a multiorgan failure developing in the pathology under consideration.

[Aspergillosis of the heart and liver in leptospirosis].

A study made in three autopsies suggested development during the second to third week of leptospirosis icterohaemorrhagica against the background of secondary immunodeficiency (due to severity of the underlying condition or induced by glucocortocoid and antibiotic therapy) Aspergillus affection of the heart that had significantly aggravated the clinical course of leptospirosis and appeared to be the immediate provoking cause of acute cardiovascular insufficiency with a fatal result to follow. Two cases demonstrated an isolated fungal infection of the myocardium. In one of these running a longer (20 days in duration) course there took place a hematogenic dissemination of the aspergilli present in the liver during the development of the metastatic focus in the myocardium.

[Hemostatic disorders in a severe course of icterohemorrhagic leptospirosis (a clinico-morphological study)].

Morphologic studies were made on the brain tissue and internal organs of those deceased (n = 75) who had died of leptospirosis icterohemorrhagica during different periods of the condition, with the results obtained being compared to clinical and laboratory findings. It has been shown that realization of the pathogenic potential of the disease-producing germ is exercised both through direct generalized injury to the endothelium of microvessels, parenchymal cells (predominantly those of the liver and kidneys) by toxic substances of Leptospira and (to a larger degree) through disorders of hemostasis presented as thrombosis of vessels of the microcirculatory bed with subsequent development of hemorrhagic manifestations and alterative changes of hypoxic genesis in vital organs. Early haemocoagulatory disorders are characterized by marked and stable hypocoagulation, with direction of the processes of fibrin formation and fibrinolysis being different, which fact is consistent with diversity of structural formations originating from fibrin in the microcirculatory bed of the deceased.

[The clinico-morphological characteristics of the nervous system lesions in icterohemorrhagic leptospirosis].

A total of 120 patients were examined presenting with a grave course of icterohemorrhagic leptospirosis; a pathomorphologic investigation of the brain from 75 deceased was done. Practically in all cases, the affection was accompanied by neurotoxicosis, with microcirculatory disturbances being its morphological substrate. The leading clinical syndromes of the affection of the central nervous system appeared to be general cerebral, meningeal, and encephalitic syndromes.

[Infectious-toxic shock and disseminated intravascular coagulation in a pregnant woman with influenza].

A pregnant female died of generalized influenza resulting in infectious-toxic shock and disseminated intravascular coagulation (DIC). DIC syndrome development was probably facilitated by placental detachment and increased blood coagulation potential characteristic for pregnancy. Multiple thrombosis of microcirculation vessels of the kidneys, pituitary, myocardium and other organs prevailed over hemorrhages typical for toxic influenza without pregnancy.

[Infectious toxic shock in generalized rotaviral infection in newborns].

The possibility of the rotavirus infection generalization, the course of which was complicated by the infectious toxic shock and disseminated intravascular coagulation syndrome as a cause of death of three newborns is shown for the first time. Etiology of the disease was established by electron microscopy, immunoenzymatic and immunofluorescent methods in the faeces, blood and postmortem material. The manifestations of giant cell metamorphosis not only in the intestine but also in the pia mater, kidneys, liver, lungs characteristic of RNA-viral infections indirectly confirmed the presence of viremia.

[Morphologic aspects of hemostasis disturbances in meningococcemia in children].

21 children who died from meningococcemia were studied. Shock disturbances of the microcirculation and thrombocytic part of hemostasis prevailed within first hours of the disease in the form of adrenal hemorrhages and brain edema as immediate cause of death. With an increase of the disease duration, aggregational thrombocytopenia, generalized microthrombosis, coagulopathy, fibrinolysis activation resulted in massive hemorrhages in a number of organs and tissues and manifested in the syndrome of polyorganic failure.

[Interferon type I in protective body reactions in an experimental Klebsiella infection].

The study on mice with experimental generalized Klebsiella infection, carried out with the use of microbiologic, immunologic and pathomorphologic methods, revealed that the intraperitoneal injection of type I interferon into the animals prevented their death and led to the rapid elimination of the infective agent from their body, enhanced the phagocytic and metabolic activity of polymorphonuclear lymphocytes of their peritoneal exudate, decreased the manifestation of microcirculatory and dystrophic changes in the parenchyma of their internal organs.

[Clinico-morphological characteristics of disseminated intravascular coagulation in bacterial meningoencephalitis].

Clinical, laboratory and morphological manifestations of impaired hemostasis due to CNS bacterial infections varying in etiology were studied in 144 patients and 32 cadavers. Etiologic and age-specific features of hemocoagulatory homeostatic disorders displayed multidirectional procoagulatory, coagulatory and fibrinolytic components. Correlation of morphological evidence for the brain and viscera with clinical-laboratory findings showed that in 69% of the patients who had died of bacterial meningoencephalitis (a generalized form) there were signs of DIC syndrome.

[The protective action of interferon type I in experimental Salmonella infection].

The effect of interferon, type 1, on the course of Salmonella infection in mice has been studied. The study has shown that the injection of homologous interferon of type 1 leads to the rapid elimination of the infective agent from the blood and organs of infected mice. Morphological study has shown that the injection of the preparations of interferon of type 1 may diminish pathological changes in the organs of the infected animals and the coagulation system of their blood.

[Effect of type I interferon on the course of endotoxic shock].

The effect of type I interferon (IF) on the course of endotoxic shock was studied by morphological methods. It was found that preliminary (24 hours earlier) injection of preparations of homologous IF (10(3) ME) to ABLb/c and CC57 W mice sensitive to salmonella infection prevented the death of 90% of animals from a lethal toxic dose of the endotoxin or killed salmonellae. Preliminary injection of IF reduced sharply the intensity of morphological changes during all periods of the study.

[The pathological anatomy of pneumococcal meningoencephalitis in adults].

The results of the clinico-morphological examination of the bacteriologically confirmed meningoencephalitis in 12 autopsy cases are presented. The gravity of the clinical course of the pneumococcus meningoencephalitis is due to infectious-toxic shock the main morphological manifestation of which is disseminated intravascular coagulation. Neurotoxicosis symptoms prevailed in the clinical picture of the infectious-toxic shock even though the morphological changes characteristic of shock were found in the brain as well as in the internal organs particularly in the adrenals, lungs and kidneys.

[Acute respiratory infections in children who have died and the role of the DIC syndrome in these diseases].

The results of several years study of the acute respiratory infections (ARI) (pneumonias) are summarized. Their high frequency in dying children is found (72% of autopsy cases in all Leningrad pediatric hospitals). Their etiology is usually complex: viral ARI were in 62.

[Clinico-morphologic characteristics of pneumococcal meningoencephalitis].

A relationship between PM severity and early onset of dramatic microcirculatory disorders of the brain and viscera leading to DIC syndrome and infective toxic shock has been reported in a clinicomorphological study of 12 PM cases. Being the main PM target, the brain is afflicted more seriously. The related shock has specific features: toxicosis and brain swelling.

[Morphology of infectious-toxic shock in salmonellosis].

Clinico-morphological data on a severe course of salmonellosis (Stenley Salmonella) with the development of the infectious-toxic shock are presented. The shock was manifested by changes of the microcirculatory bed with the development of disseminated intra vascular blood coagulation (DIBC), brain and lung oedema as well as degenerative and necrobiotic lesions of the inner organs (acute tubular renal necrosis, necrobiosis and necrosis of the gastrointestinal tract epithelium, necrobiotic processes in the adrenal parenchyma, neuronal lysis etc.) as a consequence of circulatory disturbances determining the severity of the course and outcome of the disease.