[CLINICAL AND PHARMACOLOGICAL FACTORS INFLUENCING RESISTANCE TO CLOPIDOGREL IN PATIENTS WITH CARDIOVASCULAR DISEASES].

We analysed clinical and pharmacological factors influencing resistance to clopidogrel in 250 patients with cardiovascular diseases during 18 months. It was shown that the risk ofresistance depends on the form of coronary heart disease, carbohydrate metabolism, the AA genotype of CYP2C19*2 and TBS1 genes. The cardiovascular events significantly morefrequently occurred during 12 and 18 months in resistant diabetics and in the patients with an allele lacking the *2/*3 CYP2C9 gene function and AT/TT polymorphism of the thromboxane synthase gene TBS1.

[Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms].

Aim: To analyze the influence of clinical and pharmacogenetic factors on the risk of resistance to original or generic clopidogrel and that of cardiovascular events (CVE) during 12 months of follow-up.

Subjects And Methods: Two hundred and fifty patients admitted to Moscow hospitals in October 2011 to September 2012 were examined. All the patients received clopidogrel.

[The cultivation of Vero cells and human embryonic fibroblasts in serum-free media and in media with a low serum content].

The optimum composition of serum-free media has been established for cultivation of the continuous cell line Vero originated from kidney tissue of a normal African green monkey, in addition to the optimum composition of low-level serum media (2%) for cultivation of human embryonic fibroblasts. The medium DME (one of the basic media) appeared a medium of choice for both these cell types, and the best serum replacement consisted of insulin, bovine serum albumin, ethanolamine, epidermal growth factor and hydrocortisone. Under employment of this serum replacement together with the medium DME the proliferation indices for the Vero lineage and human embryonic fibroblasts were 76 and 71%, respectively.

[Treatment of exudative maxillary sinusitis with low frequency ultrasound].

Low frequency ultrasound was applied to the treatment of suppurative maxillary sinusitis. The bactericidal activity of low frequency ultrasound was measured experimentally. Its effect on the mucous membrane of rabbit maxillary sinuses when they were sonicated from within was determined.