[Drug-resistant tuberculosis in the Republic of Karelia].

The study of drug resistance (DR) trends in the Republic of Karelia (2000-2005) indicated an increase in the incidence of multidrug resistant (MDR) tuberculosis. Among the contingents of patients, there was a particularly considerable increase in MDR tuberculosis from 18.4 to 57.

[Prevalence of primary drug resistance in M. tuberculosis in four administrative areas of the North-Western Federal District of the Russian Federation].

The paper describes the results of radiometric BACTEC assay of drug susceptibility of Mycobacterium tuberculosis strains, isolated from 81 new cases of tuberculosis, to first- and second-line antituberculosis drugs in four administrative areas of the North-Western Federal District of the Russian Federation. The results of determination of drug susceptibility to the antituberculosis drugs by the absolute concentration method and the BACTEC method are also compared. Primary drug resistance has been revealed in 58.

[Indications and contraindications to glomectomy in patients with bronchial asthma].

Thirty-year experience in surgical treatment of more than 3,000 patients with severe and moderately severe bronchial asthma showed that unilateral glomectomy produces a stable positive result in 69.5% of patients in follow-up repiods of two and more decades. Clinical recovery occurred in 23.

[Xenogeneic splenic perfusion in the treatment of bronchial asthma patients].

Blood morphology, external respiratory function, central hemodynamics, cellular and humoral immunity, circulating immune complexes, average molecules and leucocytic index were examined in 40 patients with a severe and average severe course of infection-dependent bronchial asthma before and after xenosplenoperfusion. Positive clinical results were noted manifested in an increase of the immune reactivity, improvement of external respiratory function. The method should be used with care due to additional sensibilization of the patient and possible bronchospasm.

[Role of intrathoracic pressure in changes in the greater and lesser circulation hemodynamics in patients with bronchial asthma].

The greater and lesser circulation hemodynamics was examined in 59 patients with bronchial asthma and 23 controls by tetrapolar rheography, kinetocardiography, and ultrasonic Doppler cardiography. Simultaneously measurements of intrathoracic pressure (ITP) were carried out with an esophageal controller. Reduced stroke index, increased total peripheral resistance of the vessels, and elevated systolic pressure in the pulmonary artery were revealed in the patients as against the controls.