[Usage of flavonoids for effective correction of functional and structural breaches of erythrocytes membranes during an extraordinary physical strain in experiments].

The effect of treatment course of bioflavonoids quercetin and diquertin on phospholipids and fatty acid composition of erythrocytes membranes and amilorid-dependent activity Na+/H+ transmembrane exchanger of erythrocytes have been studied in condition of chronic physical tension in mice in consequence of extraordinary running strain. The studied drugs actively prevented from the changes of chemical composition and as a result structural and functional changes of erythrocytes membranes. It is established that the studied bioflavonoids prevented from the development of extraordinary physical strain syndrome.

[Nanotechnology applications in pharmacology].

The applications of nanotechnology to pharmacology are reviewed. The potential applications of biochips, nanosensors, bioreactors, neural stem cells, immune nanoparticles, biodegradable polymers, and convection-enhanced drug delivery in the diagnostics and treatment of diseases are discussed. Specific attention is given to developments in chemotherapeutic means, including advanced drug delivery systems and targeted nanotherapy, which will form the basis of the future nanomedicine.

[Using carnosine and natural antioxidants for the prophylaxis of acute post-loading oxidative stress].

The effects of a submaximum single physical load with a mixed aerobic-anaerobic character (combined rowing test) on the intensity of lipid peroxidation (LPO) processes, antioxidant state of the organism, and rheological properties of blood have been studied in a group of athletes. The administration of natural antioxidants significantly decreased the LPO stress induced by the physical load, reduced the suppression of the antioxidant system of the organism, and normalized the LPO-disturbed hemorheological parameters. Antioxidants such as carnosine, cytamine, and apilac can be used as non-doping means for the accelerated recovery and increase in the physical work capacity in athletes.

[Expression of the beta-galactosidase gene in transgenic embryos of the loach Misgurnus fossilis L].

In order to study the topological characteristics of transgene expression in individuals, early loach embryos were injected with recombinant plasmid fragment, containing lacZ gene under the control of Raus sarcoma virus LTR. The expression of RSV-lacZ construct was found out in 80% of twenty-hours' embryos, 100% 2-3 days' embryos and 40% of 6-8 days' frys. Point and dot expression was observes on the surface of the head, muscle segments, the yolk sac, in the yolk, on the caudal fin.