[The VDR gene polymorphism in patients with multiple sclerosis].

Immune mechanisms play a pivotal role in the development of multiple sclerosis (MS). Vitamin D is an important biological immunoregulator acting through receptors of immunocompetent cells. Genotype and haplotype frequencies for VDR polymorphisms in a case-control study of MS have been investigated.

[The 1188 A/C ILI2B gene polymorphism in patients with multiple sclerosis and in healthy subjects of Tomsk region].

Multiple sclerosis (MS) is a multifactorial and polygenic disorder of the central nervous system, its development being under strong influence of T-helpers type I which produce anti-inflammation cytokines. Interleukin 12 (IL12) plays a key role in such polarization of the immune response. Genotyping for polymorphism of the IL12B gene in the 3'-untranslated region, coding for the p40(IL12B) subunit, has been carried out in 62 patients with MS and 129 healthy controls.

[3-year results of clinical and immunological monitoring of patients with multiple sclerosis treated by copaxone].

Tipe 1 T-helper cells are of importance in development of multiple sclerosis (MS). Copaxone (TEVA, Israel) is one of the preventive drugs, which modifies T-helpers activity. Thirty-three patients with MS were treated by copaxone for 2 years and 13 patients--for 3 years.