[Connection between severity of the course of tick-borne encephalitis with the concentration of interleukin-2 and interleukin-6 in blood].

Aim: To test IL-6 and IL-2 serum concentrations as indirect prognostic indicators in tick-borne encephalitis (TBE) course.

Material And Methods: 13 TBE patients' sera were examined for IL-2 and IL-6.

Results: IL-6 was not detected in patients with TBE fever but was detected in meningoencephalytic TBE.

[Protective activity of a bacterial plasmid, bearing the gene for the tick-borne encephalitis virus NS1 nonstructural protein].

Three intramuscular injections (50 micrograms each) with bacterial plasmid pMV45 carrying nonstructural gene of NS1 protein of tick-borne encephalitis (TBE) virus protected 88% Balb/c mice from lethal challenge with the virus. Antibodies to NS1 nonstructural protein were detected in the sera of vaccinated mice after the challenge. Absence of antibodies to E structural protein indicated absence of manifest infectious process in mice vaccinated with plasmid and challenged with a lethal dose of TBE virus.