[Impact of antihypertensive therapy on clinical status and quality of life in patients with initial manifestations of hypertensive encephalopathy].

Aim: To study the clinical and instrumental characteristics of hypertensive encephalopathy (HE) in early stages, as well as the time course of their changes during long-term antihypertensive therapy (AHT).

Subjects And Methods: Prior to and after 9-month AHT, 57 patients aged 50-70 years who had uncomplicated grades 1-2 arterial hypertension (AH) with grades I-II HE underwent comprehensive examination comprising the studies of cognitive functions, quality of life (QL), hemorheology, and hemostasis, duplex scanning of great and intracerebral vessels, echocardiography, 24-hour blood pressure monitoring, magnetic resonance imaging.

Results: Early-stage HE was characterized by more cerebral complaints, higher rates of hypertensive crises, a greater degree of psychoautonomic syndrome, and worse QL.

[Acute disorders of cerebral circulation: prognostic factors in essential hypertension].

Aim: To study subclinical signs of cerebrovascular pathology as prognostic factors of development of acute disorders of cerebral circulation (ADCC) in essential hypertension (EH).

Material And Methods: A prospective (10-13 years) cohort trial of prognostic significance of subclinical forms of cerebral pathology in EH in relation to ADCC development covered 111 men aged 45-55 years who had undergone a unified neurological and cardiological examination in 1992-1993.

Results: Such factors as disordered circulation along major arteries of the head (a relative risk 3.

[Epidemiology, clinical features and betaserc therapy of vertigo in initial and reversible cerebrovascular pathology].

The study comprised two sections: epidemiologic and clinical. The aim of the epidemiologic investigation was to determine prevalence of vertigo, including its mild cases, in patients with initial and reversible forms of cerebrovascular pathology. While screening an open population, 726 men and women aged 35-60 years have been examined using uniform program.

[The wavelet analysis at heliobiological connections].

The Wavelet analysis of the time series of the number of insults per day and the variations of heliogeophysical indices was carried out. The patterns of Wavelet coefficients for both processes show a complex nonstationary behavior and the presence of periodic and acyclic constituents on different scales. During heliogeophysipal disturbances, the energy contribution to the processes increases more than threefold compared with the mean value on scales from three to five days.

[Prognostic value of the degree of night decrease of systolic pressure in patients with mild and moderate forms of hypertension (7-9-year prospective study)].

Aim: To study a relationship between a carcadian blood pressure (BP) rhythm and cardiovascular events (CE) during 7-9 year follow-up in males with mild to moderate essential hypertension (EH).

Material And Methods: 50 males (mean age 48.6 +/- 0.

[Hypertension--main risk factor of stroke. Results of a three years register in Krasnodar].

Incidence of first stroke and stroke mortality in Krasnodar in 1997-2000 were higher compared with data of similar registers in Moskva and Novosibirsk. Hospitalization rate of patients with stroke especially of those with severe stroke was low with high 28 days and 1 year mortality. Main risk factor of stroke was hypertension which in about 2 thirds of patients was classified as mild.

[Drug methods of preventing stroke in cardiovascular diseases (a lecture)].

Basing on the results of numerous investigations it is possible to single out 4 main directions in prevention of acute failure of cerebral circulation (AFCC) in cardiovascular diseases: stroke prevention in hypertensive subjects, prevention of cardioembolic stroke in patients with cardiac arrhythmia, prevention of recurrent AFCC episodes in patients with transitory ischemic attacks and minor stroke, prevention of the stroke by inhibition of progression of carotid atherosclerosis. The best population effect in stroke prevention belongs to active detection and adequate treatment of AH because AH is involved in development of the majority of the mechanisms underlying both hemorrhagic and ischemic stroke.

[The prevention of acute disorders of cerebral circulation: the theory and the reality].

It would be valid to conduct prophylaxis of acute cerebrovascular disturbances (ACVD) in the context of state integral program of prophylaxis of the main noninfectious diseases. Its basic principles are: control of risk factors, integral approach and priority of populational strategy. The main medical directions of ACVD prophylaxis are: control of arterial hypertension and prevention of cardioembolic insult in patients with heart rhythm disorders.

[Blood pressure variability (based on 24-hour monitoring data) in mild arterial hypertension].

To evaluate the condition of target organs in patients with mild arterial hypertension (MAH) under normal and high arterial pressure variability (APV), the authors examined 84 MAH males aged 40-60 and 14 matched healthy controls. At 24-h monitoring it was revealed that 32% of MAH patients had high variability of daytime and night arterial pressure which occurred more frequently in atherosclerotic lesion of extracranial carotid artery portions. MAH patients with high APV against those with normal APV develop carotid artery atherosclerosis 3.

[The pathology of catecholamine metabolism in cerebrovascular diseases].

Blood catecholamines were investigated with high-performance liquid chromatography and electrochemical detection in 95 patients with cerebrovascular affections. On day 1-3 since ischemic apoplexy blood norepinephrine and dopamine levels increased significantly. This is possibly due to their active release from neurons in brain tissue ischemia.

[Lesions of the major arteries of the head (a population ultrasonic study)].

The screening of the random sample from an open population of males aged 40-65 was performed to compare frequency and severity of hemodynamic changes in major head arteries (MHA) due to atherosclerosis in subjects with vascular diseases and clinically normal controls. 866 of the examinees were subjected to MHA ultrasonic dopplerography. Normal circulation appeared only in 13% of the examinees.

[Atherosclerosis of the major arteries of the head and the content of lipoprotein(a) in the blood plasma].

It is established that atherosclerotic patients with impaired major arteries of the head have high concentration of blood lipoprotein (a) following ischemic disorder of cerebral circulation. Irrespectively of the clinical picture, atherosclerosis of the major head arteries correlated in severity with blood levels of lipoprotein (a). It is suggested that lipoprotein (a) can serve an essential biochemical marker of major head arteries atherosclerosis.

[The epidemiology of autonomic disorders--the autonomic dystonia syndrome--and its characteristics in cerebrovascular pathology].

To study the prevalence of vegetative dystonia (VD) and the role it plays in the pathogenesis of cerebrovascular diseases (CVD), 8,500 population of different regions of this country and patients with the main forms of CVD underwent an epidemiological study with the aid of a specially devised questionnaire. It is shown that (1) VD is highly prevalent among the healthy population; (2) the intensity of VD depends on the region of living, sex, age, occupational factors; (3) VD in patients with CVD is characterized by high intensity, especially in initial manifestations of cerebral circulatory disorders, and by a particularly severe course in menopausal women.

[Study of prevalence and structure of cerebrovascular disorders in different regions of the USSR based on simultaneous epidemiological examinations].

The authors describe the data of the screenings of the representative random samples from the open male population aged 20 to 54 years, carried out in accordance with the common program in 6 cities of this country. The prevalence of definite cases of cerebrovascular diseases (CVD) ranged from 7.7% in Moscow to 12% in Irkutsk.

[Effectiveness of a stroke prevention program in a high-risk group].

As a result of screening of males born in 1922-1931 (n = 2435) a group with a high risk for stroke development (n = 620) was identified. A total of 430 of these patients were followed up for 2 years. At the final stage the authors collected data on 80% of the patients who had undergone the primary examination and carried out a new screening of age-matched males.

[Clinical picture and dynamics of sensomotor aphasia in cerebrovascular pathology].

Thirty-seven patients (27 with ischemic and 10 with hemorrhagic strokes) were examined. The patients were followed up for 1 to 5 years. Clinical and neuropsychologic examinations over time and computer-aided tomography of the brain were carried out.

[Speech disorders with localization of the vascular focus in deep structures of the dominant hemisphere of the brain].

The authors present the clinical picture and time-course of aphasia (A) in 25 patients, 18 of whom had had hemorrhagic and 7 ischemic stroke. Dynamic neuropsychological examination and computer-aided tomography (CT) of the brain were carried out. The development of marked and stable A was observed in 20% of the cases.

[Speech syndrome and its course in patients who have sustained an ischemic stroke (clinico-tomographic study)].

Clinical and tomographic examinations of 40 patients with aphasia developed after an ischemic stroke were carried out. In more than half of them no correlation between the aphasia gravity and character on the one hand, and the size and localization of the ischemic focus (or foci) in the brain on the other was noted. With similar character and gravity of the speech disorder the size and localization of the ischemic foci may be different, ad vice versa.