[Hereditary deficiency of alpha 1- antitrypsin in rats due to evolving chronic lung pathology].

W/SSM rats which are characterized by hereditary abnormal changes in the lungs, hepato- and splenomegalia and some other disturbances have also alpha 1-antitrypsin (AAT) deficiency. A study of AAT in these rats by means of isoelectrofocusing and immunoblotting with anti-AAT antibodies labelled with peroxidase has demonstrated that deficiency of the protease inhibitor is not associated with any disturbances of its synthesis or any changes of its electrophoretic properties. A higher activity of lysosomal glycosidases and proteinases was found in the liver and leukocytes of W/SSM rats.

[Distribution of C subtypes and other Tf variants in populations of the USSR].

Serum samples from seventeen Caucasoids and Mongoloid populations of the USSR were tested for transferrin (Tf) subtypes. According to Tf patterns, the Caucasoids groups had high TfC1 frequency, whereas Mongoloids are characterized by increased frequency of TfC2 suballele. The following gene frequencies were observed: TfC1 - 0.

[Polymorphism of alpha1-antitrypsin in Pamir populations. Reproductive compensation--possible mechanism for maintaining genetic diversity gor PI genes in human populations].

The distribution of the phenotype and gene frequencies of alpha 1-antitrypsin among Pamir's aborigines localized at high altitudes was studied. The Kirghizes of Murgab studied include mainly the mongoloid component in their composition. Populations of the Khuf river valley in West Pamir anthropologically belong to South caucasoids.