[Dynamics and factors regulating the intensity of free radical processes during experimental supravesical block].

Two phase alterations of induced chemoluminescence were detected in kidney homogenates and blood plasma after unilateral ureteral occlusion in rats. A high correlation was observed between the rates of free radical oxidation in the blocked kidney tissue and blood plasma. Hemodynamic alterations in the kidney, accumulation of activated phagocytes in the interstitial space and elevation of medium-weight molecules were mainly responsible for the regulation of lipid peroxidation rates.

[Blood plasma diene conjugates during the stimulation and inhibition of lipid peroxidation in dogs with different forms of healing in experimental myocardial infarct].

In experiments on 45 dogs with a model of normo-, hyper-, and hyporeactive myocardial infarction, (MI) lipid peroxidation (LP) was stimulated by ultraviolet irradiation of autologous blood and inhibited by alpha-tocopherol acetate. It is shown that changes of LP are characteristic of uncomplicated healing of normoreactive MI. Hyperactivation of LP in hyperreactive MI and its hypoactivation in hyporeactive MI are among the factors of complication of its healing by postinfarction aneurysm of the heart.

[The correction of lipid peroxidation disorders in peptic ulcer patients].

The state of lipid peroxidation (LP), antioxidant blood activity (ABA) and spontaneous chemiluminescence (SC) of the gastric mucosa was studied in 37 patients with ulcer disease. It was found that LP and ABA remained practically unchanged. At the site of the ulcerative defect and around it SC was 2-4 times higher than in the intact zone.

[The expediency of optimizing lipid peroxidation in treating complicated forms of myocardial infarct healing].

Experiments on 36 dogs revealed a relationship of inhibition and stimulation of lipid peroxidation (LPO) and reactivity of myocardial infarction (MI) concerning outcomes of healing. It is shown that in complicated IM it is necessary to optimize LPO turning its dynamics to uncomplicated disease forms. In hyperreactive MI it is judicious to use antioxidants while in hyporeactive LPO stimulation is indicated using ultraviolet radiation of the blood.

[Blood plasma diene conjugates in uncomplicated and complicated forms of the healing of experimental myocardial infarct].

The experiment on 39 dogs has shown that in MI the concentration dynamics of conjugates in the blood plasma is in accordance with the forms of its healing and has two periods of activation related, respectively, to necrotic processes and development of granular tissue in the infarction zone. The control over the changes of peroxide lipid oxidation (PLO) in MI may be regarded as one of the methods of diagnosing and foreseeing the outcomes of its healing. In optimization of MI healing, to modulate PLO appears to be advisable, that is, to make its course typical of noncomplicated MI.