[Association of the nicotine and cigarette smoke toxicants metabolic (CHRNA3/5, CYP2A6, NQO1) and DNA repair genes (XRCC1, XRCC3, XPC, XPA) with chronic obstructive pulmonary disease].

The contribution of the polymorphic markers of the CHRNA5/A3, CYP2A6, NQO1, XPC, XRCC1, XRCC3, XPD, XPA genes to chronic obstructive pulmonary disease has been assessed. For this purpose, analysis of the gene polymorphisms in case/control groups in Tatar population has been performed. The CHRNA5 (rs16969968) (P = 0.

[Total and allergic morbidity trends in the population residing in the area of microbiological industry].

Due to exposure to emissions from a protein-vitamin concentrate-manufacturing enterprise, the total and allergic morbidity rates remained high in the Blagoveshchensk population during a follow-up, the incidence of asthma and atopic dermatitis being on the rise and that of pollen disease on the decrease. The findings show the need for a further follow-up of the health status of the population of this area, the living conditions in which are risk factors for allergic and toxic allergic diseases even after microbiological industry closure.