[Long-term results of treatment for T-cell lymphoblastic lymphomas].

Aim: To define the efficiency of the GMALL 2002 program for the treatment of patients with T-cell lymphoblastic lymphomas (T-LBL).

Subjects And Methods: Twenty-five patients with a verified diagnosis of T-LBL were examined. Male/female ratio was 19:6; median age was 33 (range 16-67) years.

[Diagnosis and treatment of skin T-cell lymphoma undergoing transformation in lymphosarcoma].

Aim: To define complex of parameters characterizing transformation of skin T-cell tumors in lymphosarcoma; to show specific treatment of patients with this transformation.

Material And Methods: Of 57 patients with primary T-cell lymphomas of the skin (mycosis fungoides, Sezary's disease), we studied 12 patients with transformation of the process into lymphosarcoma by clinical, histological, moleculobiological and immunophenotypical parameters.

Results: We found that transformation of T-cell lymphoma into lymphosarcoma occurred in different time from the disease onset (2-12 years).

[High-dose polychemotherapy of patients with poor-prognosis anaplastic T.0-large cell ALK+ lymphosarcoma].

Aim: To evaluate efficacy of the protocol NHL BFM-90 in the treatment of adult anaplastic large cell lymphosarcoma (ALCL) ALK+ and validity of addition of transplantation of autologous stem hemopoietic cells (ASHC) into first line treatment.

Material And Methods: We treated 13 patients with stage III-IV ALCL ALK+. The age of the patients ranged from 17 to 44 years (median 26 years).

[Efficacy of therapy of different variants of anaplastic large T-cell lymphomas].

Aim: To compare efficacy of NHL-BFM-90 and CHOP-like courses in the treatment of anaplastic large cell lymphoma (ALCL).

Material And Methods: Twenty-two patients with ALCL participated in the study. The diagnosis was made basing on the findings of clinical, device, morphological, immunohistochemical and molecular-genetic examinations with application of a panel of monoclonal antibodies to CD30, ALK, CD3, CD4, CDS, CD7, CD34, CD15, CD68, CD20, CD45RO, CD45RA, Ki-67.

[Determination of T-cell clonicity by a T-cell receptor gamma-chain: final data].

Aim: To test diagnostic efficacy of T-cell clonicity determination by a gamma-chain of T-cell receptor (TCR).

Material And Methods: The examination covered 426 patients (458 tests). T-cell tumors were detected in 132 patients.

[Clinicomorphological characteristics of Sezary's disease and mycosis fungoides].

Aim: To try a combined approach to the study of clinicomorphological and immunophenotypical characteristics of primary cutaneous T-cell lymphomas.

Material And Methods: Clinical, histological, genotypic and immunophenotypical parameters were studied in 7 patients (4 male and 3 female, mean age 53.1 +/- 7.

[Characteristics of a clinical course of immune cytopenias with a high titer of autoantibodies to the microsomal antigen of the thyroid gland].

Aim: To ascertain the role of high antibodies (Ab) titers to microsomal antigen (MA) of the thyroid in clinical manifestations of cytopenic syndromes.

Material And Methods: Clinical data are presented on 144 patients with depressed hemopoiesis having different levels of thyroid Aab.

Results: When the titer was significantly elevated (41% patients with immune cytopenias), hematological malignancies run with recurrences, remission is rare.

[Use of polymerase chain reaction for determining T-cell clonality].

Aim: To distinguish T-cell lymphomas and reactive T-cell proliferation it is important to confirm the ability of T-cells to be cloned. Conventional histological and immunophenotypic methods fail to determine the ability of T-cells to be cloned. An experience in the use of detection of T-cell receptor gene gamma-chain (TCRy) rearrangement for determining T-cellular clonality is described.

[T-cell tumors with aplastic syndromes].

Aim: To detect and verify the existence of a specific form of T-cell tumor accompanied by isolated lesions of bone marrow and aplastic syndromes.

Material And Methods: Four patients with aplastic syndromes were examined using clinical, histological, cytological, cytogenetic, and immunophenotypic methods.

Results: Four cases of T-cell tumors of bone marrow with clinical and morphological manifestations of aplastic syndrome and scanty proliferation activity in bone marrow alone were diagnosed.

[Autoantibodies to the thyroid gland in hemoblastoses and cytopenias].

Aim: To study the level of thyroid antibodies (TAB) in blood diseases.

Material And Methods: TAB levels dynamics was studied in 413 patients with hematological diseases.

Results: Increased incidence of cases with high Ab titer to thyroid microsomal antigen was found.

[Use of thymodepressin for treating autoimmune cytopenia].

Aim: To study influence of thymodepressin on the course of autoimmune cytopenia.

Material And Methods: Thymodepressin is a new synthetic hemoregulatory dipeptide (gamma-D-Glu-D-Trp). It was used for the treatment of 22 patients with autoimmune cytopenia.

[Postradiation recovery of hematopoiesis in mice affected by Neogen (IEW)].

The effect of the synthetic peptide IEW (Neogen) with immunomodulating properties on postradiation recovery of haemopoiesis was investigated. We have shown that Neogen is a potential stimulator of haemopoiesis. The administration of Neogen after irradiation shortened duration of period of the recovery of the compartment of CFU-S-8 and the amount of bone marrow cells.

[Radiation damage of the thyroid gland as a probable cause of increased incidence of non-Hodgkin lymphoma and other hematologic diseases].

Th distribution of autoimmune thyroiditis in the patients with diseases of blood system was investigate. The attribute of autoimmune thyroiditis was revealed by the detection of antimicrosomal antibodies. It was established that the autoimmune thyroiditis are more often in patients with various hematological diseases than in control group.

[The probable sequelae of thyroid damage from radioactive iodine during the Chernobyl accident].

An important peculiarity of the Chernobyl catastrophe is the discharge into the atmosphere of tremendous amount of radioactive iodine and, as a result, selective damage of the thyroid in children from the affected areas. The most dangerous consequence is the thyroid cancer. The analysis of the situation when children's thyroids were subjected to irradiation shows that tumors can most frequently develop as late as 20-30 years after irradiation.

[Local despiralization of DNA in lymphocytes of patients with chronic lympholeukemia].

DNA isolated from blood lymphocytes of 43 patients with chronic lymphoid leukemia was studied for the content of local despiralized sites by the kinetic formaldehyde method. The patients were classified into three groups: before, during and after chemotherapy by cytostatic drugs (cyclophosphamide or chlorambucil). It is found that DNA from leukosis lymphocytes contain more despiralized sites as against to DNA from normal lymphocytes and that after chemotherapy a degree of DNA despiralization decreases.

[Levels of the individual immunoglobulin classes in the blood serum and saliva of patients with various stages of chronic lympholeukemia].

Secretory serum immunoglobulins were studied in 25 patients with chronic lymphoid leukemia. The relationship between the lowering of the content of serum immunoglobulins and the disease stage was revealed as was the interrelationship between the rate of bacterial complications and the decrease in the immunoglobulin content. The content of serum and secretory IgA in the saliva of all the patients was found to be normal or elevated whatever the disease stage.