[The morphogenesis of intramedullary cavities and of a glial-connective tissue cicatrix and the enzyme status of the proteolytic system in experimental spinal cord trauma].

Canine and feline experiments were conducted to study the morphology of intramedullary cavities and a glial connective tissue cicatrix, their roles in the spinal regenerative processes as compared with the altered activity of trypsin and proteolytic inhibitors in spinal fluid and serum in different periods after spinal dissection. It was shown that decreased diastasis between the ends of the cut spine, enclosure of a traumatic area from liquor of the subarachnoidal space and central canal reduced the number and area of cavities in the cerebral cicatrix and contributed to improved regeneration of intraspinal fibers. Spinal injury caused a significant increase in trypsin and to changes of the antiprotease activity of inhibitors, spinal fluid, particularly in early postoperative periods.

[Mechanism of formation of intramedullary cavities and their role in the regeneration of the spinal cord].

The spinal cord preparations of 38 dogs and 20 rabbits have been studied with the aim to investigate the influence of the cerebrospinal fluid on the spinal cord nervous tissue. The spinal cord preparations of 8 patients having trauma of the vertebral column with interruption of the spinal cord have also been studied. As demonstrate histological investigations, the cerebral tissue of the pieces, put into the flask with liquor, in the subarachnoidal space of the canine spinal cord, in diastasis between the ends of the cut spinal cord during 6 h up to 7 days, swells, becomes edematous.