[Disorders in the interferon system in patients with virus-associated and chlamydial infections].

A more than 80% incidence of herpes simplex virus, cytomegalovirus, and chlamydial infection was revealed in 58 patients with various gynecological diseases. In 50% cases the infection was mixed. An appreciable reduction of the gamma-interferon system was detected in 20 patients, which was caused by a concomitant infectious process, possibly provoking the development of the underlying disease.

[Development of immunity to the poliomyelitis virus in infants with various methods of administering a live poliomyelitis vaccine].

The data have been obtained which indicate that the effectiveness of vaccination with live trivalent poliomyelitis vaccine may be increased and 90--100% of the vaccinated infants under 1 year of age may develop marked resistance of the alimentary tract and high antibody titers in the blood serum to the threee types of poliomyelitis virus in the course of 3 vaccinations. Some regularities of the formation of immunity to individual poliomyelitis virus types in the course of 4 vaccinations with trivalent vaccine were revealed and specified. The results indicate that the contact of vaccine virus with the oropharyngeal tissues during immunization has a favourable effect on the development of immunity.

[Change in the level of immunoglobulins A in the intestines of children after administration of live trivalent poliomyelitis vaccine by different methods].

It was shown that titers of the neutralizing activity of fecal extracts (coproantibody, CA) to poliomyelitis virus type II in the course of four administrations of live trivalent poliovaccine in drops directly into the mouth and in capsules were higher than CA titers to poliomyelitis virus types I and III. Particularly low CA titers to poliovirus types I and III were in children given the vaccine in the capsule, that is directly into the gastro-intestinal tract. Accordingly IgA levels in fecal extracts in this group of children were lower than in those given the vaccine in drops.

[Dynamics of secretory and serum immunoglobulins in children in the course of vaccinations with live poliomyelitis monovaccines].

The influence of vaccination with live poliomyelitis monovaccines on the formation of immunoglobulins in the blood serum and the buccal secrets was studied in infants under 1 year. There was a correlation between rises in the levels of serum immunoglobulins (Ig) of the A, G, and M classes and titers of neutralizing antibody to the three poliomyelitis virus types. The highest level of secretory IgA was observed after immunization with type I monovaccine.

[Effect of various methods of administration of live poliovirus vaccine on the immunoglobulin levels in the blood serum and mouth mucosa secretion in children].

Oral vaccination with live trivalent poliomyelitis in the liquid form in drops exerts a considerable influence on the IgA content in oral cavity secretes. After immunization with same vaccine in capsules no significant changes in IgA levels could be observed in oral cavity secretes for a 18-week observation period. A considerable increase in IgA level in oral secretes in children vaccinated with vaccine in capsules was observed after a 4th administration of the vaccine given orally in drops.