[The results of long-term permixon treatment in patients with symptoms of lower urinary tracts dysfunction due to benign prostatic hyperplasia].

The trial enrolled 155 patients (mean age 65 years) with documented benign prostatic hyperplasia and lower urinary tracts symptoms (LUTS) (IPSS > 6). All the patients received permixon in a dose 160 mg twice a day for 2 years. The data on 130 patients eligible for assessment were processed statistically by dynamics of IPSS, quality of life (QOL), index of sexual function (MSF-4), size of the prostate, urodynamic and biological parameters which were estimated in 6 (V6), 12 (V12), 18 (V18) and 24 months (V24).

[Mineral water Volzhanka from Undorovskĭ spring in combined therapy of patients with nephrolithiasis and chronic pyelonephritis].

Water loading is an essential component in therapy of nephrolithiasis, especially in the presence of small ureteral concrements or fragments after extracorporeal shock-wave lithotripsy. Saluretics, furosemide in particular, cause side effects. One of these is dyselectrolytemia due to potassium loss.

[Role of electrochemical potential in urinary tract function].

Rhythmic changes produced by impulse waves, respiratory and other movements are able to convert mechanical energy of the urine in the pelvis to electric energy because urine is a high-concentration electrolyte. With filling and extension of the pelvic wall, when epithelial coating is transforming from multilayer to one-layer, its resistance to electric current lowers. Growing pelvic volume in the course of the pelvis filling is accompanied by increasing electrical potential in the pelvic wall in parallel with a decline in urothelial resistance.

[Drug-induced polyuria in the surgical treatment of patients with nephrolithiasis].

Recently, drug polyuria has found wide application in diagnosis and treatment: to detect latent urinary insufficiency, to assess functional performance of the contralateral (unaffected) kidney in nephrolithiasis and calculous pyelonephritis, to stimulate elimination of fragments of the disintegrated concrement, to check up suture impermeability after surgical repair of the urinary tracts, to outline afunctional zone in hydronephrosis. Clinical experience gives grounds for use of saluretics at certain stages of pyelolithotomy for mobilization of intrarenal pelvis and its dissection, removal of the calculus and subsequent suturing of the intrarenal pelvis. Therapeutic polyuria can also facilitate ureterolithotomy.

[beta 2-Adrenomimetics before and after extracorporeal lithotripsy].

Successful disintegration of the calculus in nephrolithiasis patients is impossible without normalization of the upper urinary tracts urodynamics in dyskinesia. We employ combined treatment with high-selective beta-2-adrenomimetic hexoprenalin (hinipral) to improve migration of the concrement fragments and therefore to prevent ureteral occlusion, acute pyelonephritis and renal colic. Hexoprenalin (hinipral) is taken 6 tablets a day or intravenously in drops (5 ml per 100 ml of saline) 3-5 days before and for 10-12 days after extracorporeal shock-wave lithotripsy.

[Drainage of the urinary tract as preparation for extracorporeal lithotripsy].

Upper urinary tract drainage in patients with chronic calculous pyelonephritis (CCP) results in not only successful anti-inflammatory and antibacterial treatment but also in more effective and safe ESWL. In 21 CCP patients with upper urinary tract drainage by means of catheter-stent, ESWL was performed using Lithostar-Plus (Siemens). Active inflammation with marked pyuria, bacteriuria and even moderate upper urinary tract dilation were indications for the upper urinary tract drainage with catheter-stent before and during ESWL in CCP patients.

[Intravenous tumor invasion in renal cancer].

Intravenous tumor invasion occurred in 84 out of 600 patients who had been operated on for carcinoma of the kidney. The inferior vena cava was thrombosed by a tumor in 54 patients. Ultrasonic examination, computed tomography, and venocavography were used in establishing the diagnosis of intravenous invasion.

[Proscar (finasteride, MSD) in the treatment of patients with prostatic hyperplasia].

The drug proskar (finasteride) belongs to 5 alpha-reductase blockers breaking the steps of prostatic adenoma pathogenesis. Proskar (Merck and Co. Inc.

[Lymphadenectomy in kidney cancer].

Metastases of renal carcinoma (RC) to lymph nodes were revealed in 121 (18.1%) patients from 667 operated on RC subjects. The frequency of lymph node involvement increases with T: T1--7.

[Comprehensive treatment with ofloxacin in pyo-inflammatory urologic diseases].

Fifteen patients with various forms of pyelonephritis and chronic cystitis were treated with ofloxacin. The drug was used in the complex antiinflammatory and detoxification therapy and in cases with indicated hemotransfusion. Ofloxacin was administered intravenously during the first days of the treatment with its later oral use.

[The therapy of chronic nonobstructive pyelonephritis].

Combined therapy for chronic nonobstructive pyelonephritis introduced by the authors includes such components as etiological, pathogenetic, resistance-stimulating. The cure was achieved in 60% of the patients.

[The selection of the treatment method in stenosis of the pelviureteral segment in nephrolithiasis].

Ureteropelvic stenoses in nephrolithiasis are suggested to be considered reversible and irreversible depending on the lesions of the upper urinary tracts and the adjacent fat. To ascertain reversibility of the stenosis, use was made of the progesterone test in view of progesterone ability to dilate the ureter. No retention changes in the upper urinary tract in the reversible stenosis can serve an indication to impulse lithotripsy.

[Use of pyelomanometry and roentgenological and television uroscopy in determining the time for nephrostomy closing].

To evaluate objectively the degree of the urodynamics recovery in patients with nephrostomy in the postoperative period and to determine the optimal times of removing the nephrostomy drainage tubes, a ++video-urodynamic study was carried out. It consisted in combined antegrade X-ray TV ++pyelo-ureteroscopy and ++trans-fistula pyelomanometry. To measure the degree of the effect of retroperitoneal pressure on urodynamics, intraperitoneal pressure was also evaluated.

[The muscle compressing the ureter and its role in the closure mechanism of the ureteral-bladder segment].

The authors indicate an important role of the locking mechanism of the vesicoureteral segment in the prevention of the retrograde regurgitation of urine into the upper urinary tracts, namely vesicoureteral reflux. They pay special attention to the fact that the knowledge of the structure of the terminal part of the ureter helps select certain appliances preventing the development of the reflux. However, the known data fail to satisfy the clinicians and explain the appearance of the reflux in some cases.

[Effect of prazosin on human prostatic adenoma tissue].

The effect of prazosin on epinephrine-induced contractions of human benign prostatic hyperplasia strips was studied. It was shown that prazosin has a pronounced adrenoblocking activity (EC50 = 5.10(-9) g/ml) but fails to affect strip contractions induced by KCL.

[Experimental stimulation by protamine sulfate of the hyperglycemic action of the diabetogenic factor].

It has been established that binding of endogenous heparin by protamine sulfate considerably accelerated and intensified the diabetogenic effect of blood plasma diabetogenic factor, present in the blood of animals with experimental alloxan diabetes.