[Pharmacokinetics of n-(5-oxynicotinoyl)-L-glutamic acid calcium salt upon bolus administration in rats and rabbits: interspecies extrapolation].

The pharmacokinetics of N-(5-oxynicotinoyl)-L-glutamate (ONG) was studied in rats (doses, 20, 100 and 500 mg/kg) and rabbits (50 mg/kg) after bolus administration of calcium salt of N-(5-oxynicotinoyl)-L-glutamic acid (Ampasse preparation). The ONG concentration in the blood serum was determined by HPLC assay with fluorimetric detection. The lower limit of accurate detection for ONG was 100 ng/ml.

[Age-related characteristics of ceftazidime pharmacokinetics in children].

To reveal possible age-dependent variations in the ceftazidime pharmacokinetics, the drug plasma concentrations were determined by HPLC in 10 children aged 2 to 13 years with peritonitis. The blood specimens were collected 0.25, 0.

[Individualization of the amikacin administration regimen on the basis of the relationship between its pharmacokinetics and the patient's status].

Dosage individualization based on quantitative relationships between pharmacokinetic parameters and anatomophysiological and/or pathological factors, patient's factors (PFs) is of importance in designing optimal regimens. Unfortunately, the attempts to correlate aminoglycoside pharmacokinetic parameters and PFs often failed perhaps due to insufficient numbers of PFs under investigation. That is why we sought to involve more PFs, especially nontraditional ones, for explaining intersubject variability of the amikacin model-independent parameter in 20 patients with purulent inflammatory processes.

[Determination of the kanamycin B content of kanamycin preparations by column chromatography].

Kanamycin B content in kanamycin preparations was determined with column chromatography and PMR spectroscopy. It was shown that coincidence of the results obtained with both the procedures in analysis of the preparations subjected to additional recrystallization was satisfactory. With the use of nonrecrystallized preparations the admixtures interfered with the results in using the developed procedure.

[Sisomicin. The mechanism of admixture inactivation and formation].

Inactivation of sisomicin in aqueous solutions was studied under various conditions. At pH 4-10 and a temperature of 60 degrees C the inactivation rate constant was equal to (5-10) X 10(-5) hour-1 and remained stable. At lower pH values the inactivation rate constant increased: 5.

[Cephalosporin C stability in aqueous solutions].

Stability of cephalosporin C in aqueous solutions at various temperatures was studied. The kinetic parameters of the inactivation process providing estimation of the inactivation rate constant of cephalosporin C at pH 0-12.5 and various temperatures were evaluated.

[Gentamicin stability and a method for its quantititive determination].

Stability of gentamycin in solutions at various pH levels was studied. It was shown that in acid media inactivation proceeded according to the equation of the 1st order reaction. Dependence of the inactivation rate constant on the temperature corresponded to Arrenium equation.