[Comparative antihistamine and anti-allergic effects of various antihistamine preparations].

Aim: To compare antihistaminic and antiallergic activity of antihistaminic drugs of the latest generation (ebastin, cetirisine, fexofenadine, loratadine) and antihistaminic drugs of the first generation (clemastin) in the same patients with pollenosis.

Material And Methods: Skin prick-titration with 10-dilution histamine and specific allergen, provocative nasal titration with 2-dilution histamine and allergen before and after a single intake of H1-antagonists were made in 30 patients in stable clinical remission of pollenosis during maximal antihistamine activity of the above drugs.

Results: Systemic administration of the known H1-antagonists suppresses histamine sensitivity of both skin and nasal mucosa in the same degree.

[The in-vivo test of the inhibition of leukocyte natural migration with aspirin and analgin in the specific diagnosis of the asthmatic triad].

Asthmatic triad (AT) is a clinical syndrome incorporating bronchial asthma (BA), recurrent nasal and sinus polyps, intolerance of aspirin, derivatives of pirasolone and other nonsteroid antiinflammatory drugs. Specific diagnosis of aspirin and analgin intolerance in patients with AT was made using the test of natural leukocyte emigration inhibition in vivo in the oral cavity. The test was performed in 22 patients with AT and 13 patients with BA with pollenosis without aspirin and analgin intolerance.

[A shock reaction from insect bites in patients with urticaria pigmentosa].

The examination of 11 urticaria pigmentosa (UP) patients included allergological history, skin prick, scarification tests and intracutaneous tests with noninfectious and bee poison allergens, total and specific serum IgE measurements, in vitro reaction of histamine release from peripheral blood basophils induced by bee poison. The response of mastocytosis patients to insect sting was characterized by a rapid (within 5 min) development of severe systemic reactions or shock. The skin reactions and serum antibodies to bee poison were not registered in 9 of 11 patients.

[A comparative study of the efficacy of Tilade and intal in atopic bronchial asthma].

The authors compared the responses of patients with atopic asthma to two cromolyn drugs of different generations, tilade and intal. As shown by clinical, allergological and immunological findings, tilade (sodium nedocromil) compared to intal is more active against atopic bronchial asthma complicated by obstructive bronchitis. It can more efficiently reduce specific and nonspecific bronchial hyperreactivity, is more potent against inflammation.

[A new Soviet allergen made from bee venom for the specific diagnosis of allergic reactions to bee stings].

Overall 46 patients with allergic reactions to bee stings were examined. As a result of making skin prick, scarification and intracutaneous tests with an allergen from bee venom, allergy to bee stings was revealed in all the 46 patients, whereas only 37 patients responded to an allergen from the bee body. Specific IgE-antibodies using RAST were detected in 29 out of 31 patients.

[The immunomodulating effect of sodium nucleinate in chronic infectious-allergic urticaria].

Based on clinical, laboratory, bacterial, allergologic and immunologic studies a group of patients with infectious allergic urticaria (IAU) was distinguished. The immunologic examination of 30 patients with IAU identified a decrease in phagocytosis. Sodium nucleinate (SN) was employed as an immunomodulator as compared to placebo.

[Disordered interferon status in patients with urticaria and angioneurotic edema against a background of frequent ARVI: its correction with reaferon].

The results of clinical, allergological, virological, and immunological examinations of patients with urticaria and angioneurotic edema against the background of frequent ARVI are presented. Disorders in the interferon system in these patients were studied. A positive anti-recurrent effect of prophylactic parenteral course of a national recombinant alpha 2-interferon (reaferon) in this pathology has been demonstrated.

[Clinico-immunologic characteristics of acute toxic-allergic reactions to drugs and current methods for their treatment].

The paper is concerned with clinicoimmunological and allergological characterization of 29 cases of acute toxic allergic reactions (ATAR) to drugs. Four degrees of severity of disease were identified; the most severe form was toxic epidermal necrolysis caused by the use of sulfanilamides and pyrazolones in patients with acute respiratory virus and bacterial infections. Blood analysis in patients with III-IV degree of severity showed a sharp decrease in Ctot and C3 up to 0, an increase in the level of circulating immunocomplexes and "average molecules".

[Allergic pollen-induced myocarditis].

The paper concerns two cases of allergic pollen myocarditis. The diagnosis was confirmed by an evident relationship of myocardial lesion to the period of pollen production by allergenic plants or parenteral injection of an allergen and with the respiratory manifestations of pollenosis. In addition to the clinical picture of myocarditis (heart pain, dyspnea, abnormal rhythm), there were also alterations in blood serum enzymes (AsG, ASL-O).

[Allergen-free wards in the treatment of pollinoses and bronchial asthma].

Two allergen-free wards (AFW) fitted out with Academician I. V. Petryanov's filters have been in operation in the Department of General Allergy of the Institute of Immunology, USSR Ministry of Health, since 1981.

[Clinico-immunological and allergological characteristics of urticaria caused by pyrazolone derivatives].

The authors describe the results of clinical, allergological and immunological examination of 35 patients with urticaria caused by pyrazolone derivatives. Clinically, the patients with pyrazolone-induced urticaria were marked by chronic diseases requiring the prolonged and frequent intake of the analgesics, pyrazolone derivatives. The allergological examination of the 35 patients with pyrazolone-induced urticaria showed that only one of the patients had pollenosis, 6 patients had IgG-mediated reactions to egg protein and one patient to penicillin.

[Correlation between the T, K and NK cell count and the IgE level in patients with atopy (pollinosis)].

In a homogenous group of patients with polyposis, IgE level was juxtaposed to the number of E-rosette-forming cells (E-RFC), K- and NK-cells. The effect of a parenterally introduced allergen (via an accelerated course hyposensibilization) was also determined upon those indices. The number of E-RFC was diminished in the patient group (53,1 +/- 3,3%) as compared with the results (67,2 +/- 2,1%) obtained from the control subjects, selected by the control method of couples.