[Evaluation of the adequacy of hypotensive therapy based on the status of the tissue oxygen system and serum lactate dehydrogenase and cytochrome oxidase activities in patients with hypertension].

Parameters of tissue oxygen regime measured by polarography and serum lactate dehydrogenase (LDG) and cytochrome oxidase (CO), oxidation-reduction enzymes, were studied in 23 patients with stable hypertension of various hemodynamic types. The nature of the tissue oxygen regime and changes observed in the isoenzymic spectra of LDG and CO were found to be associated with BP levels, hemodynamic types and BP reduction degree. The time course of these values may be useful in assessing whether the antihypertensive therapy is appropriate and in determining an optimal level of BP decrease.

[Bicomponent analysis of the contractile capacity of the heart in ischemic lesions of the myocardium (experimento-clinical study)].

A study was made of cardiac pumping capacity in animals with local myocardial ischemia (9 experiments on cats), in 25 healthy persons and 21 patients suffering from coronary heart disease with stage I-IIA circulatory insufficiency using afterload characteristics (ALC). The latter reflected correlation between left ventricular pressure and aortic blood flow in constant blood filling and in a given inotropic heart condition. For combined assessment of ALC one should know its two parameters: power (maximum pressure in the zero blood flow) and rate (maximum blood flow rate in zero antipressure).

[Combined study of central hemodynamics and microcirculation in circulatory failure patients].

The status of the central hemodynamics and microcirculatory bed was studied in 50 patients (aged 25-60 years) with coronary heart disease complicated by circulatory failure. The local tissue blood flow was investigated by the H-clearance method with an automatized apparatus made in the USSR, the capillaroscopic picture was observed with a TM-1 telecapillaroscope. The paper presents a discussion of the fact that with an increase in circulatory failure the changes in the central hemodymamics are accompanied by functional and morphologic disturbances in the microcirculatory bed.