[Acute allergy in practice of military physician].

Increasing number of patients with allergy observed in recent years is accompanied with increasing number of health encounters due to acute allergy. The sudden beginning and unpredictable course characterize acute allergy. These factors can be fatal for patient and must be treated immediately.

[Local and systemic immunological disorders in patients with subretinal proliferation].

IgM, IgG, IgA, and IgE in the subretinal fluid (SRF) of the subpopulational composition of peripheral blood T lymphocytes and the parameters of a leukocyte migration inhibition test (LMIT) were comparatively studied in patients with posttraumatic and regmatogenic retinal detachments (RD) complicated by subretinal proliferation (SP). SRF and blood samples taken from 20 patients with SP of various etiologies were studied. SRF immunoglobulins of classes M, G, A, and E were revealed in all the examinees, their higher levels being noted in patients with long-standing (more than 4 months) and severe recurrent RD.

[Immunopathogenesis of viral hepatitis C. Immunological markers of the disease progression].

Results of studies of immune response during hepatitis C virus (HCV) infection were reviewed in order to reveal immunologic markers of the disease progression. Genetic heterogeneity of HCV and immunogenetic features of the host determine heterogeneity of immune response to the virus and differences in the course of the disease and outcomes. Spontaneous elimination of HCV-infection in acute phase occurs due to vigorous and sustained multispecific Th1-response toviral antigens.

[Cytokinin inducing and antiviral activity of cycloferon on experimental herpetic infection].

Experimental data on the protective activity and the capacity for inducing the biosynthesis of some cytokins, the low molecular inductors of cycloferon, endogenic interferon of the acridanon group, in herpetic infection are presented. The herpes infection was modelled by intraperitoneal injection of herpes simplex virus, type 1 into BALB/c mice. In the animals with normal immune status cycloferon induced the formation of serum interferon (INF) in high titers (up to 1:20,000) with the peak achieved 4-8 hours after the injection of the preparation.

[The characteristics of allergic diseases in people exposed to the factors of a radiation catastrophe].

The article deals with peculiarities of allergic diseases (bronchial asthma, pre-asthma, pollinosis) in patients who were exposed to the factors of radiative, catastrophe. Screening--questionnaire was made on 381 patients who went through the Chernobyl disaster. 46 patients from this number who had various allergic diseases were chosen for specific diagnostics and immunological researches.

[Antibody-dependent cytotoxic method of determining the number of natural killer cells in the peripheral blood].

A method for assays of human peripheral blood natural killers, making use of monoclonal antibodies, has been developed. The method is unsophisticated, reagent-saving, does not involve the use of special equipment. Comparison of the results of the cytotoxic method 'with those of routine tests has shown a good correlation of the results.