[Hantavirus infection in bank voles in the natural reservoir. Part 1. Characteristics of an infection process in bank voles].

The specific features of hantavirus infection in naturally infected bank voles (Clethrionomys glareolus), the principal host of hantavirus of the serotype Puumala, were studied during long-term observation of individually marked animals in the active focus of hemorrhagic fever with renal syndrome (HFRS) in the south of Udmurtia. The infection time in the bank voles was defined by paired serum seroconversion tests. In the natural focus, hantavirus was shown to cause asymptomatic persistent infection in the bank voles with the body's peak accumulation of the virus and its environmental discharge within the first month of infection.

[The topographic zoning of natural HFRS foci in Russia].

Using large selections the unified system of landscape districting of HFRS natural foci with allocation of special geo-botanical provinces has been developed. This permits to avoid various deviations were found to appear during association of epizootiological and epidemiological indexes of separate towns and rural districts when estimating regional parameters. Adequacy of the offered system in confirmed by five-fold increase of the correlation between HFRS epizootiological parameters and antibody prevalence rate in humans.

[The disposition of natural foci of hemorrhagic fever with renal syndrome in different landscape areas of Tyumen Province].

Lungs of 3159 animals of the forest complex from 90 areas of 30 administrative districts of Tyumen Province were examined by enzyme immunoassays for antigen of hemorrhagic fever with renal syndrome (HFRS) during 5 years, 1985-1989. The antigen of HERS virus was detected in the lungs of mammals of 8 species: Clethrionomys glareolus and Cl. rutilus, Siberian and Arctic lemmings (first findings in the world), M.

[The intensity of the immune response to the hemorrhagic fever with renal syndrome virus among different population groups of Bashkortostan].

For the first time the natural immune stratum to hemorrhagic fever with the renal syndrome (HFRS) among the population of all regions of Bashkiria, a large territory with the highest morbidity level in this infection in the USSR, was studied. 9,176 persons over 15 years of age were examined by radioimmune techniques. Analysis of the immune structure of the population revealed that the share of immune males was higher than that of immune females, but the difference was less than the difference between males and females among the registered HFRS patients.

[The immune structure of the population of the Bashkir ASSR in connection with hemorrhagic fever with renal syndrome and the relation of indices of collective immunity to morbidity and the nature of the landscape].

The study of 9,176 serum samples obtained from all regions and 15 cities of Bashkiria, carried out by the method of radioimmunoassay with the use of the antigen of hemorrhagic fever with the renal syndrome (HFRS), has revealed considerable differences in the size of the natural immune stratum of the population (43.9-0.8%).

[Circulation of the virus of hemorrhagic fever with renal syndrome among small mammals in the territory of the USSR].

Over 55,000 small mammals of 72 species trapped in 62 administrative territories practically in all landscape-geographical zones of the USSR were examined in 1980-1985. The use of current laboratory methods demonstrated a wide spread of HFRS virus in the territory of this country, involvement in the epizootic process of most species of forest and steppe murine rodents and insectivora. In each landscape zone, the main carriers of the HFRS agent were established, represented, as a rule, by the basic species having a high and stable population density.

[Exact determination of the eastern border of the European portion of the nosogeographic range of the hemorrhagic fever with renal syndrome].

Radioimmunoassay was used for examinations of 21,488 serum specimens from the population of 145 areas of 8 regions and 2 republics. The immune portion comprised 8.8% to the west of the assumed border and 2.

[Time periods of antibody preservation in patients convalescing from hemorrhagic fever with renal syndrome in European foci of the infection].

The radioimmunoassay of serum samples from 76 convalescents after hemorrhagic fever with the renal syndrome (HFRS), that took place in 1964 in Ufa, revealed the presence of specific antibodies in 75% of the convalescents. The absence of antibodies may be attributed both to their loss in some of the convalescents and to mistakes in the clinical diagnosis. The study of serum samples from 19 convalescents who had the infection in 1960 during the laboratory outbreak of HFRS at the Gamaleya Institute of Epidemiology and Microbiology (Moscow) showed the presence of antibodies in all convalescents.

[Detection of natural foci of hemorrhagic fever with renal syndrome on the territory of the Komi ASSR].

Natural foci of hemorrhagic fever with the renal syndrome (HFRS) have been found for the first time in the Komi ASSR. The main source of the causative agent in this territory was Clethrionomys glareolus the average infection rate of which was 4.4% and in some areas as high as 22.

[Serologic examination of patients with hemorrhagic fever with renal syndrome in the European part of the USSR].

Certain features of humoral immunity in patients suffering from hemorrhagic fever with renal syndrome (HFRS) in the territory of the European USSR were established: a trend for increasing antibody levels for a long time after convalescence (approximately 6 months) and the lack of significant decline of antibody levels for many years (5-10). Comparative clinico-serological studies revealed the occurrence of subclinical and atypical forms of HFRS disease.

[Stratum of the population of the Bashkir ASSR with natural immunity to hemorrhagic fever with renal syndrome].

Natural immunity to hemorrhagic fever with the renal syndrome (HFRS) in the human population of the Bashkir ASSR having the highest incidence of this infection was first studied using radioimmunoassay. The antigen was a suspension of lungs of rodents from natural foci containing high antigen titres. When 1726 human sera from 8 districts and 2 towns were examined, antibodies to HFRS were found in 20.