[Unstable angina: effect of aspirin and heparin on treatment outcome in hospital patients (a double-blind, placebo-controlled study)].

Aspirin and heparin are regarded as drugs that improve a prognosis in patients with unstable angina, but their comparative efficiency has not been elucidated yet. A randomized double-blind placebo-controlled study of oral aspirin (165 mm once daily) versus intravenous infusion of heparin (1,000 units per hour) was carried out in 94 patients with acute unstable angina (the mean interval after the last anginal attack 5.7 +/- 4.

[Unstable stenocardia: the results of the intracoronary administration of fibrinolytic agents].

Intracoronary thrombolytic infusions were used in 10 patients with unstable angina and high risk of myocardial infarction (MI). Streptokinase (500,000 units per hour) was used in 9 patients, and urokinase, in one. Vascular recanalization was achieved in 4 cases where angiography showed coronary arterial occlusion by a thrombus.

[Infusion of prostaglandin E1 in resting angina resistant to conventional therapy].

Effect of 48-72 hour infusion of prostaglandin E1 (PGE1) was studied in 17 patients with angina refractory to conventional medical treatment (combination of propranolol, 160 mg/day nifedipin, 30 mg/day and nitrates) by the double blind test. PGE1 was infused to 11, placebo to 6 patients. There was no difference between PGE1 and placebo groups in the number of ischemic episodes and duration of myocardial ischemia as evidenced by Holter ECG monitoring.