[The influence of local changes in the temperature-dependent conformational mobility of thioredoxins on their thermostability].

For the development of a method for the prediction of single point mutations substantially affecting protein thermostability, we studied the effect of the E85R and R82E mutations on the thermostability of thioredoxins from Escherichia coli (Trx) and Bacillus acidocaldarius (BacTrx), respectively. The basic method of investigation was the molecular dynamics simulation of 3D protein models in a particular solvent at different temperatures (300 and 373 K). Some thermolabile regions in Trx, BacTrx, and their mutants were revealed by analyzing the temperature effect on the molecular dynamics of the protein molecule.

[Problems in establishing special pensions for locomotive team workers].

The paper deals with a physiological rationale for fixing pensions for locomotive-drivers within the ranges of age and length of service. The study is based on the fact that the nature and conditions of their work accelerate their ageing and decrease their working capacity.