[Dynamics of microsymbiocenoses of upper respiratory tract in normal state and in pathology].

Aim: Study of features of interaction of bacteria in microsymbiocenoses of upper respiratory tract in dynamics in individuals with various state of health: healthy individuals, individuals after tonsillitis and bacteria carriers.

Materials And Methods: Modification of pathogenicity factors (hemolytic, lecitovitellase, lysozyme and anti-lysozyme activity) in intermicrobial interactions of 226 strains of microorganisms isolated during quintuple analysis of upper respiratory tract biocenoses of examined individuals was studied. A hierarchical structure of each microbiocenosis was built based on the data obtained, and its temporal dynamics evaluated.

[Mechanisms of bacteria translocation in generalized chronic parodontitis].

Peculiarities of behavior reactions of bacteria-symbionts created conditions for the selection of translocators-strains. In microsymbiocenosis of parodontal pockets, from which translocation of bacteria into the blood was observed, the number of signals from intermicrobial communication, inhibiting the expression of the factors of colonization, virulence and persistence, was decreasing. Meanwhile, the number of signals on the increase of the expression of the factors given was increased.

[Structural and functional characteristics of human microsymbiocenosis].

Aim: To study hierarchical structure of microbial microbiocenosis in tonsils accounting for the behavioral reactions of bacteria.

Materials And Methods: Intermicrobial interactions in 100 biocenosis on the surface of tonsillar mucosa were studied in healthy persons, carriers of bacteria and patients with chronic tonsillitis. Number of commands made by symbionts and directions of commands for modification (suppression, upregulation) of pathogenicity factors (hemolytic, lecitovitellase, lysozyme, and antilysozyme activity) was studied.