[The significance of exacerbations of lung diseases in the development of chronic cor pulmonale and their treatment].

In 61 patients, pulmonary tuberculosis was complicated by thrombosis of the pulmonary artery or its embolism and by bronchial asthma. In various lung diseases, there was a combination of some factors predisposing to chronic cor pulmonale. These included specific infection, sympathoadrenal activation, reduced capillaries, and hypoxia in pulmonary tuberculosis, alveolar hypoventilation with arteriolar spasms, and elevated intrathoracic pressure in bronchial asthma; higher pulmonary arterial systolic pressure due to spasms of the pulmonary branches and drastically reduced arterial bed in pulmonary thromboembolism.

[Significance of cyclic nucleotides in pathogenesis of cor pulmonale in tuberculosis of respiratory organs and the use of beta adrenoblockers].

Blood levels of cyclic nucleotides and their actions on central hemodynamics were studied in 129 patients with pulmonary tuberculosis. A direct correlation was established between heart rate, pulmonary artery systolic pressure and concentrations of cyclic adenosine monophosphate. Basing on this finding, the authors propose introduction of beta-adrenoblockers in hyperkinetic circulation tuberculous patients to prevent cor pulmonale.

[Ventricular ejection fraction in oxygen therapy of patients with pulmonary tuberculosis].

Radionuclide study of ejection fraction of the right heart ventricle was carried out in lung tuberculosis patients with respiratory insufficiency and cor pulmonale. Oxygen therapy was found to promote reduction of right ventricle heart failure in effective treatment of lung tuberculosis. The greatest reduction of heart failure was recorded in cases where oxygen therapy was combined with cardiac glycosides.

[Classification of respiratory insufficiency in pulmonary tuberculosis].

605 patients with different forms of pulmonary tuberculosis were examined. Blood gases and acid-base condition (ABC) were studied. In 22.

[The effect of nitroglycerin on the external respiration function and central hemodynamics in patients with tuberculosis of the lungs].

To estimate the effect of nitroglycerin (NTG) on the external respiration function and central hemodynamics, 124 patients with various forms of pulmonary tuberculosis and chronic nonspecific diseases of the lungs were examined. The indices of the external respiration function, central hemodynamics, pulmonary artery systolic pressure (PASP), general pulmonary resistance (GPR) and blood gaseous composition were determined before and after NTG sublingual use in a dose of 1 mg. It was noted that improvement of bronchial patency after the use of NTG was not significant and subsequently its indication as an agent arresting bronchospasm is not expedient.