[Studying the regression pattern of stage II and III retinopathy of prematurity by means of morphometric analysis of retinal vessels in different terms after laser retinal photocoagulation].

Dynamic evaluation of the diameters of central fundus vessels, 2nd order and peripheral vessels as well as the tortuosity index of central zone arteries in stage II and III retinopathy of prematurity (ROP), which showed regression after laser treatment, was performed. Obtained data can be used for estimation of the optimal follow-up period ensuring early detection of high probability for ROP progression after laser coagulation and decrease of the number of diagnostic examinations for patients whose pathologic process is resolving.

[Retinal vessels in retinopathy of prematurity].

Purpose: To define diagnostic morphometric parameters of central fundus and peripheral retinal vessels that characterize different types of retinopathy of prematurity (ROP) course.

Material And Methods: A total of 155 premature infants (310 eyes) with stage I, II, and III ROP were assessed as they were undergoing treatment in the Kaluga branch of "Eye Microsurgery" complex during 2010-2012. Patients with the same stage of the disease were divided into two groups according to the type of ROP course (type 1--ROP with low risk of progression, type 2--ROP with high risk of progression).

[Intraocular electrochemical lysis at the stage of endoresection of uveal melanoma (clinical experimental study)].

Introduction of novel techniques of tumor destruction allows endoresection to be a perspective eye-preserving method of uveal melanoma treatment. Further investigations are essential to assess endoresection efficacy.

[Pattern retinal laser coagulation in treatment of aggressive posterior retinopathy of prematurity].

Efficacy of pattern scanning laser coagulation in treatment of aggressive posterior retinopathy of prematurity (ROP) was evaluated. 25 premature neonates (50 eyes) with aggressive posterior ROP were examined and divided into two groups. 13 infants (26 eyes) of the 1st group underwent pattern laser coagulation performed using automanual scanning laser ophthalmologic coagulator.

[Use of perfluorocarbon emulsions for administration of photosensitizing preparations into bone marrow stem cells].

It has been shown that, upon incubation of mouse bone marrow stem cells (BMSC) in vitro with the nanoparticles of perfluorocarbon (PFC) emulsion stabilized by proxanol 268, these nanoparticles penetrate into cells and stay there for a long time (up to 20 days of observation). It has been found that, under in vitro conditions, mouse BMSC loaded with the nanoparticles of both the original emulsion and the emulsion preliminarily incubated with radachlorine do not differ from control stem cells in the rate of division, stretching on a plastic support, and the formation of a monolayer. It has been shown that the exposure to laser radiation of BMSC incubated with the nanoparticles of a PFC emulsion preliminarily incubated with radachlorine under in vitro conditions leads to the death of these cells due to the destruction of the cell membrane.