Bioaccumulation and biomagnification of arsenic in the muscle and liver of the speckled guitarfish Pseudobatos glaucostigmus in Santa Rosalía, Gulf of California, Mexico.

Arsenic (As) concentrations were measured in the muscle and liver of the speckled guitarfish Pseudobatos glaucostigmus and its main prey Penaeus californiensis, in Santa Rosalia, western Gulf of California, to determine bioaccumulation and biomagnification. Higher mean wet weight (w.w.

Increased Endocytosis of Cadmium-Metallothionein through the 24p3 Receptor in an In Vivo Model with Reduced Proximal Tubular Activity.

The proximal tubule (PT) is the major target of cadmium (Cd) nephrotoxicity. Current dogma postulates that Cd complexed to metallothionein (MT) (CdMT) is taken up through receptor-mediated endocytosis (RME) via the PT receptor megalin:cubilin, which is the predominant pathway for reuptake of filtered proteins in the kidney. Nevertheless, there is evidence that the distal parts of the nephron are also sensitive to damage induced by Cd.

Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule.

Cadmium (Cd) in the environment is a significant health hazard. Chronic low Cd exposure mainly results from food and tobacco smoking and causes kidney damage, predominantly in the proximal tubule. Blood Cd binds to thiol-containing high (e.