Necrotic Cell Death and Inflammasome NLRP3 Activity in -Infected Bovine Macrophages.

is a facultative intracellular bacterium that produces cellular necrosis in granulomatous lesions in bovines. Although -induced inflammation actively participates in granuloma development, its role in necrotic cell death and in bovine macrophages has not been fully explored. In this study, we evaluate the effect of AN5 and its culture filtrate protein extract (CFPE) on inflammasome activation in bovine macrophages and its consequences on cell death.